Toxic effects of dietary exposure to T-2 toxin on intestinal and hepatic biotransformation enzymes and drug transporter systems in broiler chickens

► Broiler chickens were exposed to 68 or 752μgT-2/kg feed for 3weeks. ► A reduced BW gain was observed when feeding 752μgT-2/kg feed. ► 752μgT-2/kg feed led to downregulation of hepatic CYP1A4, CYP1A5, CYP3A37, MRP2. ► 752μgT-2/kg feed led to higher CYP3A activity in ileum and liver. ► Both biotrans...

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Veröffentlicht in:	Food and chemical toxicology 2013-05, Vol.55, p.150-155
Hauptverfasser:	Osselaere, A., Li, S.J., De Bock, L., Devreese, M., Goossens, J., Vandenbroucke, V., Van Bocxlaer, J., Boussery, K., Pasmans, F., Martel, A., De Backer, P., Croubels, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATP Binding Cassette Transporter, Subfamily B - metabolism ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism ATP-Binding Cassette Sub-Family B Member 4 Base Sequence Biological and medical sciences Biotransformation Body Weight - drug effects Broiler chickens Chickens cytochrome P-450 Cytochrome P-450 Enzyme System - metabolism Cytochrome P450 Diet dietary exposure DNA Primers Drug transporter mechanisms drugs enzyme activity enzymes feed contamination gene expression gene expression regulation genes ileum Intestinal Mucosa - metabolism Intestines - drug effects Intestines - enzymology liver Liver - drug effects Liver - enzymology Liver - metabolism Medical sciences messenger RNA microsomes Plant poisons toxicology Polymerase Chain Reaction reverse transcriptase polymerase chain reaction T-2 toxin T-2 Toxin - toxicity toxicity Toxicology
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