Polyphenols isolated from Allium cepa L. induces apoptosis by suppressing IAP-1 through inhibiting PI3K/Akt signaling pathways in human leukemic cells

•Polyphenols extracted from Allium cepa Linn (PEAL) induced caspase-dependent apoptosis in human leukemia cells.•PEAL up-regulated TRAIL receptor DR5 and down-regulated surviving and cellular inhibitor of apoptosis 1 (cIAP-1).•PEAL induces apoptosis through the inhibition of phosphatidylinositol 3-k...

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Veröffentlicht in:	Food and chemical toxicology 2013-12, Vol.62, p.382-389
Hauptverfasser:	Han, Min Ho, Lee, Won Sup, Jung, Ji Hyun, Jeong, Jae-Hun, Park, Cheol, Kim, Hye Jung, Kim, GonSup, Jung, Jin-Myung, Kwon, Taeg Kyu, Kim, Gi-Young, Ryu, Chung Ho, Shin, Sung Chul, Hong, Soon Chan, Choi, Yung Hyun
Format:	Artikel
Sprache:	eng
Schlagworte:	Akt Allium cepa anticarcinogenic activity Antineoplastic Agents, Phytogenic - pharmacology Apoptosis Apoptosis - drug effects Biological and medical sciences caspases Caspases - metabolism cell growth Cell Line, Tumor freeze drying Hematologic and hematopoietic diseases Humans Inhibitor of Apoptosis Proteins - antagonists & inhibitors Inhibitor of Apoptosis Proteins - metabolism K562 Cells - drug effects leukemia Leukemia - drug therapy Leukemia - metabolism Leukemia - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences neoplasm cells Onions - chemistry phosphatidylinositol 3-kinase Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - metabolism Polyphenols Polyphenols - isolation & purification Polyphenols - pharmacology Proto-Oncogene Proteins c-akt - antagonists & inhibitors Proto-Oncogene Proteins c-akt - metabolism Proto-Oncogene Proteins c-bcl-2 - metabolism Receptors, TNF-Related Apoptosis-Inducing Ligand - metabolism signal transduction Signal Transduction - drug effects therapeutics Toxicology TRAIL U937 Ubiquitin-Protein Ligases - antagonists & inhibitors Ubiquitin-Protein Ligases - metabolism
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