Vancomycin and Piperacillin-Tazobactam Against Methicillin-Resistant Staphylococcus aureus and Vancomycin-Intermediate Staphylococcus aureus in an In Vitro Pharmacokinetic/Pharmacodynamic Model

Abstract Purpose Synergy between β-lactams and vancomycin against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-intermediate Staphylococcus aureus (VISA) has been observed in vitro and in vivo. However, studies investigating piperacillin-tazobactam with vancomycin against MRSA an...

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Veröffentlicht in:	Clinical therapeutics 2014-10, Vol.36 (10), p.1334-1344
Hauptverfasser:	Dilworth, Thomas J., PharmD, Leonard, Steve N., PharmD, Vilay, A. Mary, PharmD, Mercier, Renée-Claude, PharmD
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacokinetics Anti-Bacterial Agents - pharmacology Biological and medical sciences combination therapy Drug Synergism Internal Medicine Medical Education Medical sciences Methicillin Resistance - drug effects methicillin-resistant Staphylococcus aureus Microbial Sensitivity Tests Models, Biological Penicillanic Acid - analogs & derivatives Penicillanic Acid - pharmacokinetics Penicillanic Acid - pharmacology Pharmacology. Drug treatments Piperacillin - pharmacokinetics Piperacillin - pharmacology piperacillin-tazobactam Staphylococcus aureus Staphylococcus aureus - drug effects vancomycin Vancomycin - pharmacokinetics Vancomycin - pharmacology Vancomycin Resistance - drug effects vancomycin-intermediate Staphylococcus aureus
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