Pre-clinical safety assessment of the synthetic human milk, nature-identical, oligosaccharide Lacto-N-neotetraose (LNnT)

•We present the safety data generated on a potential new human milk oligosaccharide.•The HMO in question is Lacto-N-neotetraose (LNnT) produced by chemical synthesis.•LNnT was non-mutagenic in two in vitro assays.•Oral administration to rats over 90days was not associated with any adverse effects.•A...

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Veröffentlicht in:	Food and chemical toxicology 2013-12, Vol.62, p.528-537
Hauptverfasser:	Coulet, Myriam, Phothirath, Phoukham, Constable, Anne, Marsden, Edward, Schilter, Benoit
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral adverse effects Animals Biological and medical sciences Body Weight - drug effects breast milk Chemical mutagenesis clinical trials cows Dose-Response Relationship, Drug feed intake Female gastrointestinal system Gavage genotoxicity histopathology Human milk oligosaccharides Humans in vitro studies infant formulas ingredients Juvenile rats juveniles LNnT Male Medical sciences Mice milk Milk, Human - chemistry Mutagenicity Mutagenicity Tests no observed adverse effect level oligosaccharides Oligosaccharides - administration & dosage Oligosaccharides - pharmacology Oligosaccharides - toxicity oral administration Rats Rats, Wistar safety assessment Sub-chronic toxicity synthesis Toxicity Tests - methods Toxicology weight gain
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