In vivo evidence for greater amphetamine-induced dopamine release in pathological gambling: a positron emission tomography study with [11C]-(+)-PHNO

Drug addiction has been associated with deficits in mesostriatal dopamine (DA) function, but whether this state extends to behavioral addictions such as pathological gambling (PG) is unclear. Here we used positron emission tomography and the D 3 receptor-preferring radioligand [ 11 C]-(+)-PHNO durin...

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Veröffentlicht in:	Molecular psychiatry 2014-12, Vol.19 (12), p.1305-1313
Hauptverfasser:	Boileau, I, Payer, D, Chugani, B, Lobo, D S S, Houle, S, Wilson, A A, Warsh, J, Kish, S J, Zack, M
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378/548/1964 631/92/436 692/699/476/5 Addictions Addictive behaviors Adult Adult and adolescent clinical studies Amphetamine - pharmacology Amphetamines Behavioral Sciences Biological and medical sciences Biological Psychology Brain - diagnostic imaging Brain - drug effects Brain - metabolism Caudate-putamen Cocaine Dopamine Dopamine - metabolism Dopamine Agents - pharmacology Dopamine Agonists Dopamine D3 receptors Drug addiction Drug use Gambling Gambling - diagnostic imaging Gambling - metabolism Health care Humans Hypotheses Male Medical imaging Medical research Medical sciences Medicine Medicine & Public Health Mental disorders Mental health Miscellaneous Models, Neurological Neostriatum Neuroimaging Neuropharmacology Neurosciences original-article Oxazines Parkinson's disease Pharmacology. Drug treatments Pharmacotherapy Positron emission tomography Psychiatry Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychopharmacology Radiopharmaceuticals Receptors, Dopamine D3 - metabolism Severity of Illness Index Social behavior disorders. Criminal behavior. Delinquency Substance use disorder Substantia nigra Tomography
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