Chemical composition of total flavonoids from Salvia chinensia Benth and their pro-apoptotic effect on hepatocellular carcinoma cells: Potential roles of suppressing cellular NF-κB signaling

•TSFC induces HCC cell apoptosis in vitro and in vivo.•TSFC suppresses NF-κB activity in HCC cells.•TSFC exhibits low toxic effects to tumor-bearing mice. Salvia chinensia Benth (S. chinensia) is a medical plant that has been traditionally applied for centuries in the treatment of malignant diseases...

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Veröffentlicht in:	Food and chemical toxicology 2013-12, Vol.62, p.420-426
Hauptverfasser:	Xiang, Meixian, Su, Hanwen, Hu, Yajing, Hu, Yun, Yang, Tianming, Shu, Guangwen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects Biological and medical sciences Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - pathology caspases cell growth chemical composition Dose-Response Relationship, Drug Flavonoids Flavonoids - analysis Flavonoids - chemistry Flavonoids - pharmacology Flavonoids - toxicity flow cytometry Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Regulation, Neoplastic - drug effects genes Hep G2 Cells - drug effects Hepatocellular carcinoma hepatoma Humans Liver Neoplasms - drug therapy Liver Neoplasms - pathology Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Medicine, Chinese Traditional Mice Multiple tumors. Solid tumors. Tumors in childhood (general aspects) NF-kappa B - antagonists & inhibitors NF-kappa B - metabolism Nuclear factor κB Salvia Salvia - chemistry Salvia chinensia Benth tissues toxicity Toxicology transcription factor NF-kappa B Tumors
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