Detection of tetracycline and oxytetracycline residues in pig and calf hair by ultra-high-performance liquid chromatography tandem mass spectrometry
An ultra-high-performance liquid chromatography tandem mass spectrometry method to detect residues of tetracycline (TC), epi-tetracycline (eTC) and oxytetracycline (OTC) in animal hair was developed. Hair samples were washed with water, extracted with NH 4OH 0.1 M, purified by SPE-C 18 cartridge and...
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| Veröffentlicht in: | Journal of Chromatography A 2009-11, Vol.1216 (46), p.8096-8100 |
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| container_title | Journal of Chromatography A |
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| creator | Castellari, M. Gratacós-Cubarsí, M. García-Regueiro, J.A. |
| description | An ultra-high-performance liquid chromatography tandem mass spectrometry method to detect residues of tetracycline (TC), epi-tetracycline (eTC) and oxytetracycline (OTC) in animal hair was developed. Hair samples were washed with water, extracted with NH
4OH 0.1
M, purified by SPE-C
18 cartridge and analyzed by tandem mass spectrometry (ESI
+, MRM mode) with satisfactory results. For the first time, accumulation of TC, eTC and OTC was confirmed in livestock hairs after a therapeutic treatment with TC and OTC, respectively. Administered drug residues were detectable in hair samples up to 2 months after the last treatment, providing a retrospective evidence of TC and OTC administration. Hair analysis seems to offer a wider window of detection than edible tissues. |
| doi_str_mv | 10.1016/j.chroma.2009.03.059 |
| format | Article |
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4OH 0.1
M, purified by SPE-C
18 cartridge and analyzed by tandem mass spectrometry (ESI
+, MRM mode) with satisfactory results. For the first time, accumulation of TC, eTC and OTC was confirmed in livestock hairs after a therapeutic treatment with TC and OTC, respectively. Administered drug residues were detectable in hair samples up to 2 months after the last treatment, providing a retrospective evidence of TC and OTC administration. Hair analysis seems to offer a wider window of detection than edible tissues.</description><identifier>ISSN: 0021-9673</identifier><identifier>EISSN: 1873-3778</identifier><identifier>DOI: 10.1016/j.chroma.2009.03.059</identifier><identifier>PMID: 19345951</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Anti-Bacterial Agents - administration & dosage ; Anti-Bacterial Agents - analysis ; antibiotic residues ; Bacterial Infections - drug therapy ; Bacterial Infections - veterinary ; calves ; Cattle ; Chromatography, High Pressure Liquid - methods ; Drug Residues - analysis ; epitetracycline ; Hair ; Hair - chemistry ; hairs ; high performance liquid chromatography ; mass spectrometry ; Muscles - chemistry ; Oxytetracycline ; Oxytetracycline - administration & dosage ; Oxytetracycline - analysis ; Swine ; Tandem mass spectrometry ; Tandem Mass Spectrometry - methods ; Tetracycline ; Tetracycline - administration & dosage ; Tetracycline - analysis ; ultra high performance liquid chromatography</subject><ispartof>Journal of Chromatography A, 2009-11, Vol.1216 (46), p.8096-8100</ispartof><rights>2009 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-119a85b93d64888c8e26c8219a11154584e5b6aa418f05b6b7858aa8340692ed3</citedby><cites>FETCH-LOGICAL-c418t-119a85b93d64888c8e26c8219a11154584e5b6aa418f05b6b7858aa8340692ed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.chroma.2009.03.059$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19345951$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Castellari, M.</creatorcontrib><creatorcontrib>Gratacós-Cubarsí, M.</creatorcontrib><creatorcontrib>García-Regueiro, J.A.</creatorcontrib><title>Detection of tetracycline and oxytetracycline residues in pig and calf hair by ultra-high-performance liquid chromatography tandem mass spectrometry</title><title>Journal of Chromatography A</title><addtitle>J Chromatogr A</addtitle><description>An ultra-high-performance liquid chromatography tandem mass spectrometry method to detect residues of tetracycline (TC), epi-tetracycline (eTC) and oxytetracycline (OTC) in animal hair was developed. Hair samples were washed with water, extracted with NH
4OH 0.1
M, purified by SPE-C
18 cartridge and analyzed by tandem mass spectrometry (ESI
+, MRM mode) with satisfactory results. For the first time, accumulation of TC, eTC and OTC was confirmed in livestock hairs after a therapeutic treatment with TC and OTC, respectively. Administered drug residues were detectable in hair samples up to 2 months after the last treatment, providing a retrospective evidence of TC and OTC administration. Hair analysis seems to offer a wider window of detection than edible tissues.</description><subject>Animals</subject><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Anti-Bacterial Agents - analysis</subject><subject>antibiotic residues</subject><subject>Bacterial Infections - drug therapy</subject><subject>Bacterial Infections - veterinary</subject><subject>calves</subject><subject>Cattle</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Drug Residues - analysis</subject><subject>epitetracycline</subject><subject>Hair</subject><subject>Hair - chemistry</subject><subject>hairs</subject><subject>high performance liquid chromatography</subject><subject>mass spectrometry</subject><subject>Muscles - chemistry</subject><subject>Oxytetracycline</subject><subject>Oxytetracycline - administration & dosage</subject><subject>Oxytetracycline - analysis</subject><subject>Swine</subject><subject>Tandem mass spectrometry</subject><subject>Tandem Mass Spectrometry - methods</subject><subject>Tetracycline</subject><subject>Tetracycline - administration & dosage</subject><subject>Tetracycline - analysis</subject><subject>ultra high performance liquid chromatography</subject><issn>0021-9673</issn><issn>1873-3778</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcuO1TAMhiMEYg4Db4AgSzYtubRNukFCw1UaiQXMOkpT9zRHbdNJWkTfgwfGZ3okxIZVIvuz_ds_IS85yznj1dtT7voYRpsLxuqcyZyV9SNy4FrJTCqlH5MDY4JndaXkFXmW0okxrpgST8kVr2VR1iU_kN8fYAG3-DDR0NEFlmjd5gY_AbVTS8Ov7Z9YhOTbFRL1E5398YFxduhob32kzUbXAems98c-myF2IY52ckAHf796RB8UL-EY7dxvdMFyGOloU6JpRhmYxWnbc_Kks0OCF5f3mtx9-vjj5kt2--3z15v3t5kruF4yzmury6aWbVVorZ0GUTktMMo5L4tSF1A2lbUIdwx_jdKltlbLglW1gFZekzd73zmGe9xqMaNPDobBThDWZHglSyaEqhiixY66GFKK0Jk5-tHGzXBmzn6Yk9m3M2c_DJMG_cCyV5cJazNC-7foYgACr3egs8HYY_TJ3H0XjEtsic6pM_FuJwAv8dNDNMl5wKO2PuLJTBv8_zX8AQzRqgg</recordid><startdate>20091113</startdate><enddate>20091113</enddate><creator>Castellari, M.</creator><creator>Gratacós-Cubarsí, M.</creator><creator>García-Regueiro, J.A.</creator><general>Elsevier B.V</general><general>Amsterdam; New York: Elsevier</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QH</scope><scope>7UA</scope><scope>C1K</scope><scope>F1W</scope><scope>H97</scope><scope>L.G</scope></search><sort><creationdate>20091113</creationdate><title>Detection of tetracycline and oxytetracycline residues in pig and calf hair by ultra-high-performance liquid chromatography tandem mass spectrometry</title><author>Castellari, M. ; Gratacós-Cubarsí, M. ; García-Regueiro, J.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-119a85b93d64888c8e26c8219a11154584e5b6aa418f05b6b7858aa8340692ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Anti-Bacterial Agents - administration & dosage</topic><topic>Anti-Bacterial Agents - analysis</topic><topic>antibiotic residues</topic><topic>Bacterial Infections - drug therapy</topic><topic>Bacterial Infections - veterinary</topic><topic>calves</topic><topic>Cattle</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Drug Residues - analysis</topic><topic>epitetracycline</topic><topic>Hair</topic><topic>Hair - chemistry</topic><topic>hairs</topic><topic>high performance liquid chromatography</topic><topic>mass spectrometry</topic><topic>Muscles - chemistry</topic><topic>Oxytetracycline</topic><topic>Oxytetracycline - administration & dosage</topic><topic>Oxytetracycline - analysis</topic><topic>Swine</topic><topic>Tandem mass spectrometry</topic><topic>Tandem Mass Spectrometry - methods</topic><topic>Tetracycline</topic><topic>Tetracycline - administration & dosage</topic><topic>Tetracycline - analysis</topic><topic>ultra high performance liquid chromatography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Castellari, M.</creatorcontrib><creatorcontrib>Gratacós-Cubarsí, M.</creatorcontrib><creatorcontrib>García-Regueiro, J.A.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aqualine</collection><collection>Water Resources Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><jtitle>Journal of Chromatography A</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Castellari, M.</au><au>Gratacós-Cubarsí, M.</au><au>García-Regueiro, J.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Detection of tetracycline and oxytetracycline residues in pig and calf hair by ultra-high-performance liquid chromatography tandem mass spectrometry</atitle><jtitle>Journal of Chromatography A</jtitle><addtitle>J Chromatogr A</addtitle><date>2009-11-13</date><risdate>2009</risdate><volume>1216</volume><issue>46</issue><spage>8096</spage><epage>8100</epage><pages>8096-8100</pages><issn>0021-9673</issn><eissn>1873-3778</eissn><abstract>An ultra-high-performance liquid chromatography tandem mass spectrometry method to detect residues of tetracycline (TC), epi-tetracycline (eTC) and oxytetracycline (OTC) in animal hair was developed. Hair samples were washed with water, extracted with NH
4OH 0.1
M, purified by SPE-C
18 cartridge and analyzed by tandem mass spectrometry (ESI
+, MRM mode) with satisfactory results. For the first time, accumulation of TC, eTC and OTC was confirmed in livestock hairs after a therapeutic treatment with TC and OTC, respectively. Administered drug residues were detectable in hair samples up to 2 months after the last treatment, providing a retrospective evidence of TC and OTC administration. Hair analysis seems to offer a wider window of detection than edible tissues.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>19345951</pmid><doi>10.1016/j.chroma.2009.03.059</doi><tpages>5</tpages></addata></record> |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Animals Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - analysis antibiotic residues Bacterial Infections - drug therapy Bacterial Infections - veterinary calves Cattle Chromatography, High Pressure Liquid - methods Drug Residues - analysis epitetracycline Hair Hair - chemistry hairs high performance liquid chromatography mass spectrometry Muscles - chemistry Oxytetracycline Oxytetracycline - administration & dosage Oxytetracycline - analysis Swine Tandem mass spectrometry Tandem Mass Spectrometry - methods Tetracycline Tetracycline - administration & dosage Tetracycline - analysis ultra high performance liquid chromatography |
| title | Detection of tetracycline and oxytetracycline residues in pig and calf hair by ultra-high-performance liquid chromatography tandem mass spectrometry |
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