Geraniin down regulates gamma radiation-induced apoptosis by suppressing DNA damage

•Geraniin raise an ionizing radiation-induced apoptotic threshold.•Geraniin regulates p53-dependent apoptosis of splenocytes after irradiation.•Geraniin attenuate radiation-induced damage by reducing DNA breakage and apoptosis.•Geraniin protects mouse splenocytes and jejunal crypt cells from ionizin...

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Veröffentlicht in:	Food and chemical toxicology 2013-07, Vol.57, p.147-153
Hauptverfasser:	Bing, So Jin, Ha, Danbee, Kim, Min Ju, Park, Eunjin, Ahn, Ginnae, Kim, Dae Seung, Ko, Ryeo Kyeong, Park, Jae Woo, Lee, Nam Ho, Jee, Youngheun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antioxidant activity Apoptosis Apoptosis - drug effects Apoptosis - radiation effects aquatic plants bcl-2-Associated X Protein - metabolism Biological and medical sciences Biological effects of radiation Cell Proliferation - drug effects Cell Proliferation - radiation effects Cells, Cultured DNA damage DNA Damage - drug effects DNA Damage - radiation effects Fundamental and applied biological sciences. Psychology gamma radiation Gamma Rays Genes, p53 Geraniin Glucosides - administration & dosage Glucosides - pharmacology Glucosides - toxicity Hydrolyzable Tannins - administration & dosage Hydrolyzable Tannins - pharmacology Hydrolyzable Tannins - toxicity Injections, Intraperitoneal intestinal crypts Intestine, Small - drug effects Intestine, Small - pathology Intestine, Small - radiation effects Ionizing radiations irradiation Jejunal crypt cells jejunum Jejunum - cytology Jejunum - drug effects Jejunum - radiation effects Medical sciences Mice Mice, Inbred C57BL Nymphaea Nymphaea - chemistry Nymphaea tetragona Proto-Oncogene Proteins c-bcl-2 - metabolism radiation injury Radiation, Ionizing Radiation-Protective Agents - pharmacology Radioprotection radioprotective agents Spleen - cytology Spleen - drug effects Spleen - pathology Splenocytes stem cells Tissues, organs and organisms biophysics Toxicity Tests, Acute Toxicology Whole-Body Irradiation γ-irradiation
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