Simultaneous quantification of ethylpurine adducts in human urine by stable isotope dilution nanoflow liquid chromatography nanospray ionization tandem mass spectrometry

•Analysis of 3-ethyladenine and 7-ethylguanine in human urine.•Adduct enrichment by a polymeric reversed phase solid-phase extraction column.•Sensitive analysis by stable isotope dilution nanoflow LC-NSI/MS/MS. Ethylating agents contained in cigarette smoke can damage DNA producing ethylated DNA add...

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Veröffentlicht in:	Journal of Chromatography A 2013-12, Vol.1322, p.69-73
Hauptverfasser:	Chen, Hauh-Jyun Candy, Lin, Chao-Ray
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Ethyladenine 7-Ethylguanine Biological and medical sciences biomarkers Carbon Isotopes Chromatography, Liquid - methods cigarettes detection limit DNA adduct DNA Adducts DNA damage Humans Indicator Dilution Techniques ionization isotope dilution technique Limit of Detection liquid chromatography Mass spectrometry Medical sciences Nanoflow LC neoplasms Nitrogen Isotopes Purines - urine Solid Phase Extraction stable isotopes tandem mass spectrometry Tandem Mass Spectrometry - methods Tobacco, tobacco smoking Toxicology Urine
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