Stress and excitatory synapses: From health to disease

Highlights • Stress can result in highly adaptive responses but is also an important risk factor for disease. • Acute stress rapidly enhances excitatory synaptic transmission and promotes learning and memory processes. • Chronic stress reduces excitatory synaptic transmission and learning and memory...

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Veröffentlicht in:Neuroscience 2013-09, Vol.248, p.626-636
Hauptverfasser: Timmermans, W, Xiong, H, Hoogenraad, C.C, Krugers, H.J
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container_title Neuroscience
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creator Timmermans, W
Xiong, H
Hoogenraad, C.C
Krugers, H.J
description Highlights • Stress can result in highly adaptive responses but is also an important risk factor for disease. • Acute stress rapidly enhances excitatory synaptic transmission and promotes learning and memory processes. • Chronic stress reduces excitatory synaptic transmission and learning and memory. • Early life experience has long-lasting effects on excitatory synaptic transmission and dendritic complexity.
doi_str_mv 10.1016/j.neuroscience.2013.05.043
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subjects Adaptation, Physiological
Adrenal Cortex Hormones - physiology
AMPA
Anxiety Disorders - etiology
Anxiety Disorders - physiopathology
Biological and medical sciences
corticosterone
Depressive Disorder - etiology
Depressive Disorder - physiopathology
Fundamental and applied biological sciences. Psychology
Humans
Life Change Events
Neurology
Neuronal Plasticity
NMDA
Norepinephrine - physiology
plasticity
stress
Stress, Psychological - complications
Stress, Psychological - physiopathology
Stress, Psychological - psychology
synapses
Synapses - physiology
Synaptic Transmission - physiology
Vertebrates: nervous system and sense organs
title Stress and excitatory synapses: From health to disease
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