Experimental HBsAg/anti-HBs complex assay for prediction of HBeAg loss in chronic hepatitis B patients treated with pegylated interferon and adefovir

We studied whether hepatitis B surface antigen (HBsAg)/anti-HBs immune complex levels in chronic hepatitis B (CHB) patients receiving antiviral therapy could be used as a response marker at baseline (BL) or early during treatment to predict treatment outcome. An experimental array-based assay (immun...

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Veröffentlicht in:	Antiviral therapy 2014-01, Vol.19 (3), p.259-267
Hauptverfasser:	DE NIET, Annikki, JANSEN, Louis, ZAAIJER, Hans L, KLAUSE, Ursula, TAKKENBERG, Bart, JANSSEN, Harry L. A, CHU, Tom, PETRIC, Rosemary, REESINK, Hendrik W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - analogs & derivatives Adenine - therapeutic use Adult Antibiotics. Antiinfectious agents. Antiparasitic agents Antigen-Antibody Complex - blood Antiviral agents Antiviral Agents - therapeutic use Area Under Curve Biological and medical sciences DNA, Viral - blood Female Hepatitis B Antibodies - blood Hepatitis B e Antigens - blood Hepatitis B Surface Antigens - blood Hepatitis B virus Hepatitis B virus - drug effects Hepatitis B virus - immunology Hepatitis B, Chronic - blood Hepatitis B, Chronic - drug therapy Hepatitis B, Chronic - immunology Hepatitis B, Chronic - virology Human viral diseases Humans Infectious diseases Interferon-alpha - therapeutic use Male Medical sciences Middle Aged Organophosphonates - therapeutic use Pharmacology. Drug treatments Polyethylene Glycols - therapeutic use Predictive Value of Tests Protein Array Analysis Protein Binding Recombinant Proteins - therapeutic use Treatment Outcome Viral diseases Viral hepatitis
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