Differential regulation of NMDAR and NMDAR-mediated metaplasticity by anandamide and 2-AG in the hippocampus

Endocannabinoids (eCBs), including AEA and 2‐AG, are endogenous signaling mediators involved in many physiological and pathological events. The G protein‐coupled cannabinoid receptor 1 (CB1R) is an important target for eCBs, however, additional non‐CB1 receptor targets have also been identified. Alt...

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Veröffentlicht in:	Hippocampus 2014-12, Vol.24 (12), p.1601-1614
Hauptverfasser:	Yang, Kai, Lei, Gang, Xie, Yu-Feng, MacDonald, John F., Jackson, Michael F.
Format:	Artikel
Sprache:	eng
Schlagworte:	2-AG AEA Animals Arachidonic Acids - metabolism CA1 Region, Hippocampal - drug effects CA1 Region, Hippocampal - physiology Calcium - metabolism Cells, Cultured Endocannabinoids - metabolism Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology Female Glycerides - metabolism Male metaplasticity Neuronal Plasticity - drug effects Neuronal Plasticity - physiology Neurons - drug effects Neurons - physiology NMDAR Patch-Clamp Techniques Polyunsaturated Alkamides - metabolism Protein Kinase C - metabolism Proto-Oncogene Proteins pp60(c-src) - metabolism Rats, Wistar Receptor, Cannabinoid, CB1 - metabolism Receptors, N-Methyl-D-Aspartate - metabolism Tissue Culture Techniques TRPV Cation Channels - metabolism TRPV1 channels
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