The PPFIA1-PP2A protein complex promotes trafficking of Kif7 to the ciliary tip and Hedgehog signaling

The primary cilium is required for Hedgehog (Hh) signaling in vertebrates. Hh leads to ciliary accumulation and activation of the transmembrane protein Smoothened (Smo) and affects the localization of several pathway components, including the Gli family of transcriptional regulators, within differen...

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Veröffentlicht in:	Science signaling 2014-12, Vol.7 (355), p.ra117-ra117
Hauptverfasser:	Liu, Yulu C, Couzens, Amber L, Deshwar, Ashish R, B McBroom-Cerajewski, Linda D, Zhang, Xiaoyun, Puviindran, Vijitha, Scott, Ian C, Gingras, Anne-Claude, Hui, Chi-Chung, Angers, Stephane
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals Cilia - genetics Cilia - metabolism Hedgehog Proteins - genetics Hedgehog Proteins - metabolism HEK293 Cells Humans Kinesin - genetics Kinesin - metabolism Kruppel-Like Transcription Factors - genetics Kruppel-Like Transcription Factors - metabolism Mice Protein Phosphatase 2 - genetics Protein Phosphatase 2 - metabolism Proteins - genetics Proteins - metabolism Signal Transduction - physiology Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic - physiology Zebrafish - genetics Zebrafish - metabolism Zebrafish Proteins - genetics Zebrafish Proteins - metabolism Zinc Finger Protein GLI1
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