The small-molecule BGP-15 protects against heart failure and atrial fibrillation in mice

Heart failure (HF) and atrial fibrillation (AF) share common risk factors, frequently coexist and are associated with high mortality. Treatment of HF with AF represents a major unmet need. Here we show that a small molecule, BGP-15, improves cardiac function and reduces arrhythmic episodes in two in...

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Veröffentlicht in:	Nature communications 2014-12, Vol.5 (1), p.5705-5705, Article 5705
Hauptverfasser:	Sapra, Geeta, Tham, Yow Keat, Cemerlang, Nelly, Matsumoto, Aya, Kiriazis, Helen, Bernardo, Bianca C., Henstridge, Darren C., Ooi, Jenny Y. Y., Pretorius, Lynette, Boey, Esther J. H., Lim, Lydia, Sadoshima, Junichi, Meikle, Peter J., Mellet, Natalie A., Woodcock, Elizabeth A., Marasco, Silvana, Ueyama, Tomomi, Du, Xiao-Jun, Febbraio, Mark A., McMullen, Julie R.
Format:	Artikel
Sprache:	eng
Schlagworte:	692/699/75/230 692/699/75/29/1309 692/700/565/1436 Animals Atrial Fibrillation - drug therapy Caveolin 1 - metabolism Caveolin 3 - metabolism Disease Models, Animal Electrocardiography G(M3) Ganglioside - metabolism Heart Failure - prevention & control HSP70 Heat-Shock Proteins - metabolism Humanities and Social Sciences Humans Male Mice Mice, Knockout Mice, Transgenic Microarray Analysis multidisciplinary Oximes - chemistry Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Piperidines - chemistry Proto-Oncogene Proteins c-akt - metabolism Receptor, IGF Type 1 - metabolism Receptors, Somatomedin - metabolism Risk Factors Science Science (multidisciplinary) Signal Transduction Transgenes
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