Gallic Acid Regulates Skin Photoaging in UVB‐exposed Fibroblast and Hairless Mice

Ultraviolet (UV) radiation is the primary factor in skin photoaging, which is characterized by wrinkle formation, dryness, and thickening. The mechanisms underlying skin photoaging are closely associated with degradation of collagen via upregulation of matrix metalloproteinase (MMP) activity, which...

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Veröffentlicht in:	Phytotherapy research 2014-12, Vol.28 (12), p.1778-1788
Hauptverfasser:	Hwang, Eunson, Park, Sang‐Yong, Lee, Hyun Ji, Lee, Tae Youp, Sun, Zheng‐wang, Yi, Tae Hoo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anti-inflammatory activity antioxidants Antioxidants - pharmacology Cells, Cultured collagen Collagen Type I - metabolism elastin erythema fibroblasts Fibroblasts - drug effects Fibroblasts - radiation effects gallic acid Gallic Acid - pharmacology hairless mice Humans Interleukin-6 - metabolism irradiation Male Matrix Metalloproteinase 1 - metabolism metalloproteinases Mice Mice, Hairless MMP-1 photoaging protective effect protein synthesis reactive oxygen species Reactive Oxygen Species - metabolism ROS secretion Skin - drug effects Skin - radiation effects Skin Aging - drug effects Skin Aging - radiation effects topical application transcription factors Transforming Growth Factor beta1 - metabolism type I procollagen Ultraviolet Rays
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