Gallic Acid Regulates Skin Photoaging in UVB‐exposed Fibroblast and Hairless Mice
Ultraviolet (UV) radiation is the primary factor in skin photoaging, which is characterized by wrinkle formation, dryness, and thickening. The mechanisms underlying skin photoaging are closely associated with degradation of collagen via upregulation of matrix metalloproteinase (MMP) activity, which...
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| Veröffentlicht in: | Phytotherapy research 2014-12, Vol.28 (12), p.1778-1788 |
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| creator | Hwang, Eunson Park, Sang‐Yong Lee, Hyun Ji Lee, Tae Youp Sun, Zheng‐wang Yi, Tae Hoo |
| description | Ultraviolet (UV) radiation is the primary factor in skin photoaging, which is characterized by wrinkle formation, dryness, and thickening. The mechanisms underlying skin photoaging are closely associated with degradation of collagen via upregulation of matrix metalloproteinase (MMP) activity, which is induced by reactive oxygen species (ROS) production. Gallic acid (GA), a phenolic compound, possesses a variety of biological activities including antioxidant and antiinflammatory activities. We investigated the protective effects of GA against photoaging caused by UVB irradiation using normal human dermal fibroblasts (NHDFs) in vitro and hairless mice in vivo. The production levels of ROS, interlukin‐6, and MMP‐1 were significantly suppressed, and type I procollagen expression was stimulated in UVB‐irradiated and GA‐treated NHDFs. GA treatment inhibited the activity of transcription factor activation protein 1. The effects of GA following topical application and dietary administration were examined by measuring wrinkle formation, histological modification, protein expression, and physiological changes such as stratum corneum hydration, transepidermal water loss, and erythema index. We found that GA decreased dryness, skin thickness, and wrinkle formation via negative modulation of MMP‐1 secretion and positive regulation of elastin, type I procollagen, and transforming growth factor‐β1. Our data indicate that GA is a potential candidate for the prevention of UVB‐induced premature skin aging. Copyright © 2014 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/ptr.5198 |
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The mechanisms underlying skin photoaging are closely associated with degradation of collagen via upregulation of matrix metalloproteinase (MMP) activity, which is induced by reactive oxygen species (ROS) production. Gallic acid (GA), a phenolic compound, possesses a variety of biological activities including antioxidant and antiinflammatory activities. We investigated the protective effects of GA against photoaging caused by UVB irradiation using normal human dermal fibroblasts (NHDFs) in vitro and hairless mice in vivo. The production levels of ROS, interlukin‐6, and MMP‐1 were significantly suppressed, and type I procollagen expression was stimulated in UVB‐irradiated and GA‐treated NHDFs. GA treatment inhibited the activity of transcription factor activation protein 1. The effects of GA following topical application and dietary administration were examined by measuring wrinkle formation, histological modification, protein expression, and physiological changes such as stratum corneum hydration, transepidermal water loss, and erythema index. We found that GA decreased dryness, skin thickness, and wrinkle formation via negative modulation of MMP‐1 secretion and positive regulation of elastin, type I procollagen, and transforming growth factor‐β1. Our data indicate that GA is a potential candidate for the prevention of UVB‐induced premature skin aging. Copyright © 2014 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.5198</identifier><identifier>PMID: 25131997</identifier><identifier>CODEN: PHYREH</identifier><language>eng</language><publisher>England: Heyden & Son</publisher><subject>Animals ; anti-inflammatory activity ; antioxidants ; Antioxidants - pharmacology ; Cells, Cultured ; collagen ; Collagen Type I - metabolism ; elastin ; erythema ; fibroblasts ; Fibroblasts - drug effects ; Fibroblasts - radiation effects ; gallic acid ; Gallic Acid - pharmacology ; hairless mice ; Humans ; Interleukin-6 - metabolism ; irradiation ; Male ; Matrix Metalloproteinase 1 - metabolism ; metalloproteinases ; Mice ; Mice, Hairless ; MMP-1 ; photoaging ; protective effect ; protein synthesis ; reactive oxygen species ; Reactive Oxygen Species - metabolism ; ROS ; secretion ; Skin - drug effects ; Skin - radiation effects ; Skin Aging - drug effects ; Skin Aging - radiation effects ; topical application ; transcription factors ; Transforming Growth Factor beta1 - metabolism ; type I procollagen ; Ultraviolet Rays</subject><ispartof>Phytotherapy research, 2014-12, Vol.28 (12), p.1778-1788</ispartof><rights>Copyright © 2014 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4118-34226eafe727b66640ac1a74b0d2182ad4315352f66670f683a285ca5a6b893c3</citedby><cites>FETCH-LOGICAL-c4118-34226eafe727b66640ac1a74b0d2182ad4315352f66670f683a285ca5a6b893c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fptr.5198$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fptr.5198$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25131997$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hwang, Eunson</creatorcontrib><creatorcontrib>Park, Sang‐Yong</creatorcontrib><creatorcontrib>Lee, Hyun Ji</creatorcontrib><creatorcontrib>Lee, Tae Youp</creatorcontrib><creatorcontrib>Sun, Zheng‐wang</creatorcontrib><creatorcontrib>Yi, Tae Hoo</creatorcontrib><title>Gallic Acid Regulates Skin Photoaging in UVB‐exposed Fibroblast and Hairless Mice</title><title>Phytotherapy research</title><addtitle>Phytother. Res</addtitle><description>Ultraviolet (UV) radiation is the primary factor in skin photoaging, which is characterized by wrinkle formation, dryness, and thickening. The mechanisms underlying skin photoaging are closely associated with degradation of collagen via upregulation of matrix metalloproteinase (MMP) activity, which is induced by reactive oxygen species (ROS) production. Gallic acid (GA), a phenolic compound, possesses a variety of biological activities including antioxidant and antiinflammatory activities. We investigated the protective effects of GA against photoaging caused by UVB irradiation using normal human dermal fibroblasts (NHDFs) in vitro and hairless mice in vivo. The production levels of ROS, interlukin‐6, and MMP‐1 were significantly suppressed, and type I procollagen expression was stimulated in UVB‐irradiated and GA‐treated NHDFs. GA treatment inhibited the activity of transcription factor activation protein 1. The effects of GA following topical application and dietary administration were examined by measuring wrinkle formation, histological modification, protein expression, and physiological changes such as stratum corneum hydration, transepidermal water loss, and erythema index. We found that GA decreased dryness, skin thickness, and wrinkle formation via negative modulation of MMP‐1 secretion and positive regulation of elastin, type I procollagen, and transforming growth factor‐β1. Our data indicate that GA is a potential candidate for the prevention of UVB‐induced premature skin aging. Copyright © 2014 John Wiley & Sons, Ltd.</description><subject>Animals</subject><subject>anti-inflammatory activity</subject><subject>antioxidants</subject><subject>Antioxidants - pharmacology</subject><subject>Cells, Cultured</subject><subject>collagen</subject><subject>Collagen Type I - metabolism</subject><subject>elastin</subject><subject>erythema</subject><subject>fibroblasts</subject><subject>Fibroblasts - drug effects</subject><subject>Fibroblasts - radiation effects</subject><subject>gallic acid</subject><subject>Gallic Acid - pharmacology</subject><subject>hairless mice</subject><subject>Humans</subject><subject>Interleukin-6 - metabolism</subject><subject>irradiation</subject><subject>Male</subject><subject>Matrix Metalloproteinase 1 - metabolism</subject><subject>metalloproteinases</subject><subject>Mice</subject><subject>Mice, Hairless</subject><subject>MMP-1</subject><subject>photoaging</subject><subject>protective effect</subject><subject>protein synthesis</subject><subject>reactive oxygen species</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>ROS</subject><subject>secretion</subject><subject>Skin - drug effects</subject><subject>Skin - radiation effects</subject><subject>Skin Aging - drug effects</subject><subject>Skin Aging - radiation effects</subject><subject>topical application</subject><subject>transcription factors</subject><subject>Transforming Growth Factor beta1 - metabolism</subject><subject>type I procollagen</subject><subject>Ultraviolet Rays</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10M9u1DAQBnALgehSkHgCiMSFS4rHf-L4WArdAgVW3W7pzZokzuLWmyx2Itobj8Az8iR4tUuRkDhZI__0aeYj5CnQA6CUvVoP4UCCLu-RCVCtc5CK3ycTqiXkAsrLPfIoxitKqWZUPCR7TAIHrdWEzKfovauzw9o12Zldjh4HG7P5teuy2dd-6HHpumWWpsXF618_ftqbdR9tkx27KvSVxzhk2DXZCbrgbYzZR1fbx-RBiz7aJ7t3nyyO354fneSnn6fvjg5P81oAlDkXjBUWW6uYqoqiEBRrQCUq2jAoGTaCg-SStelP0bYoObJS1iixqErNa75PXm5z16H_Nto4mJWLtfUeO9uP0UDBJaWpF5Hoi3_oVT-GLm23UUIwrpn-G1iHPsZgW7MOboXh1gA1m6JNKtpsik702S5wrFa2uYN_mk0g34Lvztvb_waZ2fnZLnDnXRzszZ3HcG0KxZU0Xz5Nzfs3FzMNHy4NS_751rfYG1wGF81iziiki6FUCjT_Dcdpnac</recordid><startdate>201412</startdate><enddate>201412</enddate><creator>Hwang, Eunson</creator><creator>Park, Sang‐Yong</creator><creator>Lee, Hyun Ji</creator><creator>Lee, Tae Youp</creator><creator>Sun, Zheng‐wang</creator><creator>Yi, Tae Hoo</creator><general>Heyden & Son</general><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201412</creationdate><title>Gallic Acid Regulates Skin Photoaging in UVB‐exposed Fibroblast and Hairless Mice</title><author>Hwang, Eunson ; Park, Sang‐Yong ; Lee, Hyun Ji ; Lee, Tae Youp ; Sun, Zheng‐wang ; Yi, Tae Hoo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4118-34226eafe727b66640ac1a74b0d2182ad4315352f66670f683a285ca5a6b893c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>anti-inflammatory activity</topic><topic>antioxidants</topic><topic>Antioxidants - pharmacology</topic><topic>Cells, Cultured</topic><topic>collagen</topic><topic>Collagen Type I - metabolism</topic><topic>elastin</topic><topic>erythema</topic><topic>fibroblasts</topic><topic>Fibroblasts - drug effects</topic><topic>Fibroblasts - radiation effects</topic><topic>gallic acid</topic><topic>Gallic Acid - pharmacology</topic><topic>hairless mice</topic><topic>Humans</topic><topic>Interleukin-6 - metabolism</topic><topic>irradiation</topic><topic>Male</topic><topic>Matrix Metalloproteinase 1 - metabolism</topic><topic>metalloproteinases</topic><topic>Mice</topic><topic>Mice, Hairless</topic><topic>MMP-1</topic><topic>photoaging</topic><topic>protective effect</topic><topic>protein synthesis</topic><topic>reactive oxygen species</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>ROS</topic><topic>secretion</topic><topic>Skin - drug effects</topic><topic>Skin - radiation effects</topic><topic>Skin Aging - drug effects</topic><topic>Skin Aging - radiation effects</topic><topic>topical application</topic><topic>transcription factors</topic><topic>Transforming Growth Factor beta1 - metabolism</topic><topic>type I procollagen</topic><topic>Ultraviolet Rays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hwang, Eunson</creatorcontrib><creatorcontrib>Park, Sang‐Yong</creatorcontrib><creatorcontrib>Lee, Hyun Ji</creatorcontrib><creatorcontrib>Lee, Tae Youp</creatorcontrib><creatorcontrib>Sun, Zheng‐wang</creatorcontrib><creatorcontrib>Yi, Tae Hoo</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hwang, Eunson</au><au>Park, Sang‐Yong</au><au>Lee, Hyun Ji</au><au>Lee, Tae Youp</au><au>Sun, Zheng‐wang</au><au>Yi, Tae Hoo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gallic Acid Regulates Skin Photoaging in UVB‐exposed Fibroblast and Hairless Mice</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother. Res</addtitle><date>2014-12</date><risdate>2014</risdate><volume>28</volume><issue>12</issue><spage>1778</spage><epage>1788</epage><pages>1778-1788</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><coden>PHYREH</coden><abstract>Ultraviolet (UV) radiation is the primary factor in skin photoaging, which is characterized by wrinkle formation, dryness, and thickening. The mechanisms underlying skin photoaging are closely associated with degradation of collagen via upregulation of matrix metalloproteinase (MMP) activity, which is induced by reactive oxygen species (ROS) production. Gallic acid (GA), a phenolic compound, possesses a variety of biological activities including antioxidant and antiinflammatory activities. We investigated the protective effects of GA against photoaging caused by UVB irradiation using normal human dermal fibroblasts (NHDFs) in vitro and hairless mice in vivo. The production levels of ROS, interlukin‐6, and MMP‐1 were significantly suppressed, and type I procollagen expression was stimulated in UVB‐irradiated and GA‐treated NHDFs. GA treatment inhibited the activity of transcription factor activation protein 1. The effects of GA following topical application and dietary administration were examined by measuring wrinkle formation, histological modification, protein expression, and physiological changes such as stratum corneum hydration, transepidermal water loss, and erythema index. We found that GA decreased dryness, skin thickness, and wrinkle formation via negative modulation of MMP‐1 secretion and positive regulation of elastin, type I procollagen, and transforming growth factor‐β1. Our data indicate that GA is a potential candidate for the prevention of UVB‐induced premature skin aging. Copyright © 2014 John Wiley & Sons, Ltd.</abstract><cop>England</cop><pub>Heyden & Son</pub><pmid>25131997</pmid><doi>10.1002/ptr.5198</doi><tpages>11</tpages></addata></record> |
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| subjects | Animals anti-inflammatory activity antioxidants Antioxidants - pharmacology Cells, Cultured collagen Collagen Type I - metabolism elastin erythema fibroblasts Fibroblasts - drug effects Fibroblasts - radiation effects gallic acid Gallic Acid - pharmacology hairless mice Humans Interleukin-6 - metabolism irradiation Male Matrix Metalloproteinase 1 - metabolism metalloproteinases Mice Mice, Hairless MMP-1 photoaging protective effect protein synthesis reactive oxygen species Reactive Oxygen Species - metabolism ROS secretion Skin - drug effects Skin - radiation effects Skin Aging - drug effects Skin Aging - radiation effects topical application transcription factors Transforming Growth Factor beta1 - metabolism type I procollagen Ultraviolet Rays |
| title | Gallic Acid Regulates Skin Photoaging in UVB‐exposed Fibroblast and Hairless Mice |
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