Serum insulin-like growth factor 1 in the aging horse
Background Insulin‐like growth factor 1 (IGF‐1) has important roles in anabolic processes in the musculoskeletal system and has been reported to decrease with age in both people and horses. Objectives The objective of this study was to determine serum IGF‐1 levels in the aging horse from early to la...
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| Veröffentlicht in: | Veterinary clinical pathology 2014-12, Vol.43 (4), p.557-560 |
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| container_title | Veterinary clinical pathology |
| container_volume | 43 |
| creator | Lygren, Tone Hansen, Sanni Langberg, Henning Fjeldborg, Julie Jacobsen, Stine Nielsen, Mette O. Schjerling, Peter Markussen, Bo Thomsen, Preben D. Berg, Lise C. |
| description | Background
Insulin‐like growth factor 1 (IGF‐1) has important roles in anabolic processes in the musculoskeletal system and has been reported to decrease with age in both people and horses.
Objectives
The objective of this study was to determine serum IGF‐1 levels in the aging horse from early to late adulthood (age range 5–27 years).
Methods
Healthy horses (n = 72) were used in a cross‐sectional study, while 37 paired serum samples were available for a longitudinal study. Serum IGF‐1 protein was determined using an ELISA kit validated for use in equine samples.
Results
No association was found between serum IGF‐1 levels and age in the cross‐sectional study. In the longitudinal study, a latent variable model fitted to the data revealed that horses in general experienced a 5.2% increase of serum IGF‐1 levels over a 5‐year period, but horses crossing a change point around 9 years of age between the 2 samples experienced an 11.0% decrease.
Conclusions
In this study, there was no evidence for aging being a factor in changes of IGF‐1 levels in an adult and old horse population. |
| doi_str_mv | 10.1111/vcp.12201 |
| format | Article |
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Insulin‐like growth factor 1 (IGF‐1) has important roles in anabolic processes in the musculoskeletal system and has been reported to decrease with age in both people and horses.
Objectives
The objective of this study was to determine serum IGF‐1 levels in the aging horse from early to late adulthood (age range 5–27 years).
Methods
Healthy horses (n = 72) were used in a cross‐sectional study, while 37 paired serum samples were available for a longitudinal study. Serum IGF‐1 protein was determined using an ELISA kit validated for use in equine samples.
Results
No association was found between serum IGF‐1 levels and age in the cross‐sectional study. In the longitudinal study, a latent variable model fitted to the data revealed that horses in general experienced a 5.2% increase of serum IGF‐1 levels over a 5‐year period, but horses crossing a change point around 9 years of age between the 2 samples experienced an 11.0% decrease.
Conclusions
In this study, there was no evidence for aging being a factor in changes of IGF‐1 levels in an adult and old horse population.</description><identifier>ISSN: 0275-6382</identifier><identifier>EISSN: 1939-165X</identifier><identifier>DOI: 10.1111/vcp.12201</identifier><identifier>PMID: 25250671</identifier><identifier>CODEN: VCPADJ</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Aging - blood ; Animals ; Cross-Sectional Studies ; ELISA ; Enzyme-Linked Immunosorbent Assay - veterinary ; equine ; Female ; growth factors ; Horses - blood ; Horses - growth & development ; Insulin-Like Growth Factor I - analysis ; Longitudinal Studies ; longitudinal study ; Male ; senescence</subject><ispartof>Veterinary clinical pathology, 2014-12, Vol.43 (4), p.557-560</ispartof><rights>2014 American Society for Veterinary Clinical Pathology</rights><rights>2014 American Society for Veterinary Clinical Pathology.</rights><rights>Copyright © 2014 The American Society for Veterinary Clinical Pathology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3911-93db94e1a4d0db4b29df73cca46ad4412cfad783dce9c590cf81d6dece068b003</citedby><cites>FETCH-LOGICAL-c3911-93db94e1a4d0db4b29df73cca46ad4412cfad783dce9c590cf81d6dece068b003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fvcp.12201$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fvcp.12201$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25250671$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lygren, Tone</creatorcontrib><creatorcontrib>Hansen, Sanni</creatorcontrib><creatorcontrib>Langberg, Henning</creatorcontrib><creatorcontrib>Fjeldborg, Julie</creatorcontrib><creatorcontrib>Jacobsen, Stine</creatorcontrib><creatorcontrib>Nielsen, Mette O.</creatorcontrib><creatorcontrib>Schjerling, Peter</creatorcontrib><creatorcontrib>Markussen, Bo</creatorcontrib><creatorcontrib>Thomsen, Preben D.</creatorcontrib><creatorcontrib>Berg, Lise C.</creatorcontrib><title>Serum insulin-like growth factor 1 in the aging horse</title><title>Veterinary clinical pathology</title><addtitle>Vet Clin Pathol</addtitle><description>Background
Insulin‐like growth factor 1 (IGF‐1) has important roles in anabolic processes in the musculoskeletal system and has been reported to decrease with age in both people and horses.
Objectives
The objective of this study was to determine serum IGF‐1 levels in the aging horse from early to late adulthood (age range 5–27 years).
Methods
Healthy horses (n = 72) were used in a cross‐sectional study, while 37 paired serum samples were available for a longitudinal study. Serum IGF‐1 protein was determined using an ELISA kit validated for use in equine samples.
Results
No association was found between serum IGF‐1 levels and age in the cross‐sectional study. In the longitudinal study, a latent variable model fitted to the data revealed that horses in general experienced a 5.2% increase of serum IGF‐1 levels over a 5‐year period, but horses crossing a change point around 9 years of age between the 2 samples experienced an 11.0% decrease.
Conclusions
In this study, there was no evidence for aging being a factor in changes of IGF‐1 levels in an adult and old horse population.</description><subject>Aging - blood</subject><subject>Animals</subject><subject>Cross-Sectional Studies</subject><subject>ELISA</subject><subject>Enzyme-Linked Immunosorbent Assay - veterinary</subject><subject>equine</subject><subject>Female</subject><subject>growth factors</subject><subject>Horses - blood</subject><subject>Horses - growth & development</subject><subject>Insulin-Like Growth Factor I - analysis</subject><subject>Longitudinal Studies</subject><subject>longitudinal study</subject><subject>Male</subject><subject>senescence</subject><issn>0275-6382</issn><issn>1939-165X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtOwzAQRS0EglJY8AMoEhtYpPUziZeogoJUFaTy2lmO7bRp06TYCaV_jyG0CyRmM9LMmas7F4AzBHvIV_9DrXoIY4j2QAdxwkMUsbd90IE4ZmFEEnwEjp2bQ0iYHx2CI8wwg1GMOoBNjG2WQV66psjLsMgXJpjaal3PgkyqurIB8sugnplATvNyGswq68wJOMhk4czpb--C59ubp8FdOHoY3g-uR6EiHKGQE51yapCkGuqUppjrLCZKSRpJTSnCKpM6TohWhivGocoSpCNtlIFRknq7XXDZ6q5s9d4YV4tl7pQpClmaqnECRf4jSCmOPXrxB51XjS29u2-KEv8uSzx11VLKVs5Zk4mVzZfSbgSC4jtL4bMUP1l69vxXsUmXRu_IbXge6LfAOi_M5n8l8TJ43EqG7UXuavO5u5B2IaKYxEy8jocCTpIE8-GbGJMvmMiLIQ</recordid><startdate>201412</startdate><enddate>201412</enddate><creator>Lygren, Tone</creator><creator>Hansen, Sanni</creator><creator>Langberg, Henning</creator><creator>Fjeldborg, Julie</creator><creator>Jacobsen, Stine</creator><creator>Nielsen, Mette O.</creator><creator>Schjerling, Peter</creator><creator>Markussen, Bo</creator><creator>Thomsen, Preben D.</creator><creator>Berg, Lise C.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201412</creationdate><title>Serum insulin-like growth factor 1 in the aging horse</title><author>Lygren, Tone ; Hansen, Sanni ; Langberg, Henning ; Fjeldborg, Julie ; Jacobsen, Stine ; Nielsen, Mette O. ; Schjerling, Peter ; Markussen, Bo ; Thomsen, Preben D. ; Berg, Lise C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3911-93db94e1a4d0db4b29df73cca46ad4412cfad783dce9c590cf81d6dece068b003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aging - blood</topic><topic>Animals</topic><topic>Cross-Sectional Studies</topic><topic>ELISA</topic><topic>Enzyme-Linked Immunosorbent Assay - veterinary</topic><topic>equine</topic><topic>Female</topic><topic>growth factors</topic><topic>Horses - blood</topic><topic>Horses - growth & development</topic><topic>Insulin-Like Growth Factor I - analysis</topic><topic>Longitudinal Studies</topic><topic>longitudinal study</topic><topic>Male</topic><topic>senescence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lygren, Tone</creatorcontrib><creatorcontrib>Hansen, Sanni</creatorcontrib><creatorcontrib>Langberg, Henning</creatorcontrib><creatorcontrib>Fjeldborg, Julie</creatorcontrib><creatorcontrib>Jacobsen, Stine</creatorcontrib><creatorcontrib>Nielsen, Mette O.</creatorcontrib><creatorcontrib>Schjerling, Peter</creatorcontrib><creatorcontrib>Markussen, Bo</creatorcontrib><creatorcontrib>Thomsen, Preben D.</creatorcontrib><creatorcontrib>Berg, Lise C.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary clinical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lygren, Tone</au><au>Hansen, Sanni</au><au>Langberg, Henning</au><au>Fjeldborg, Julie</au><au>Jacobsen, Stine</au><au>Nielsen, Mette O.</au><au>Schjerling, Peter</au><au>Markussen, Bo</au><au>Thomsen, Preben D.</au><au>Berg, Lise C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum insulin-like growth factor 1 in the aging horse</atitle><jtitle>Veterinary clinical pathology</jtitle><addtitle>Vet Clin Pathol</addtitle><date>2014-12</date><risdate>2014</risdate><volume>43</volume><issue>4</issue><spage>557</spage><epage>560</epage><pages>557-560</pages><issn>0275-6382</issn><eissn>1939-165X</eissn><coden>VCPADJ</coden><abstract>Background
Insulin‐like growth factor 1 (IGF‐1) has important roles in anabolic processes in the musculoskeletal system and has been reported to decrease with age in both people and horses.
Objectives
The objective of this study was to determine serum IGF‐1 levels in the aging horse from early to late adulthood (age range 5–27 years).
Methods
Healthy horses (n = 72) were used in a cross‐sectional study, while 37 paired serum samples were available for a longitudinal study. Serum IGF‐1 protein was determined using an ELISA kit validated for use in equine samples.
Results
No association was found between serum IGF‐1 levels and age in the cross‐sectional study. In the longitudinal study, a latent variable model fitted to the data revealed that horses in general experienced a 5.2% increase of serum IGF‐1 levels over a 5‐year period, but horses crossing a change point around 9 years of age between the 2 samples experienced an 11.0% decrease.
Conclusions
In this study, there was no evidence for aging being a factor in changes of IGF‐1 levels in an adult and old horse population.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>25250671</pmid><doi>10.1111/vcp.12201</doi><tpages>4</tpages></addata></record> |
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| ispartof | Veterinary clinical pathology, 2014-12, Vol.43 (4), p.557-560 |
| issn | 0275-6382 1939-165X |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aging - blood Animals Cross-Sectional Studies ELISA Enzyme-Linked Immunosorbent Assay - veterinary equine Female growth factors Horses - blood Horses - growth & development Insulin-Like Growth Factor I - analysis Longitudinal Studies longitudinal study Male senescence |
| title | Serum insulin-like growth factor 1 in the aging horse |
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