Investigation of podophyllotoxin esters as potential anticancer agents: Synthesis, biological studies and tubulin inhibition properties

A series of fifteen podophyllotoxin derived esters have been synthesized and their anti-cancer properties have been evaluated against A549 (lung cancer), DU-145 (prostate cancer), HepG2 (liver cancer), HeLa (cervical cancer) and MCF-7 (breast cancer) cell lines. Five compounds of the series 8a, 8g–h...

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Veröffentlicht in:	European journal of medicinal chemistry 2015-01, Vol.89, p.128-137
Hauptverfasser:	Shareef, Mohd Adil, Duscharla, Divya, Ramasatyaveni, G., Dhoke, Neha R., Das, Amitava, Ummanni, Ramesh, Srivastava, Ajay Kumar
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apoptosis - drug effects CA-4 Cell Line, Tumor Cell Proliferation - drug effects Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Esters - chemical synthesis Esters - chemistry Esters - pharmacology Hep G2 Cells Humans MCF-7 Cells Molecular Structure Podophyllotoxin Podophyllotoxin - analogs & derivatives Podophyllotoxin - chemistry Podophyllotoxin - pharmacology Structure-Activity Relationship Tubulin - metabolism Tubulin Modulators - chemical synthesis Tubulin Modulators - chemistry Tubulin Modulators - pharmacology Tubulin polymerization inhibition
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