1-Phenylsulfinyl-3-(pyridin-3-yl)naphthalen-2-ols: A new class of potent and selective aldosterone synthase inhibitors

1-Phenylsulfinyl-3-(pyridin-3-yl)naphthalen-2-ols and related compounds were synthesized and evaluated for inhibition of aldosterone synthase (CYP11B2), a potential target for cardiovascular diseases associated with elevated plasma aldosterone levels like congestive heart failure and myocardial fibr...

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Veröffentlicht in:	European journal of medicinal chemistry 2015-01, Vol.89, p.597-605
Hauptverfasser:	Grombein, Cornelia M., Hu, Qingzhong, Heim, Ralf, Rau, Sabrina, Zimmer, Christina, Hartmann, Rolf W.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phenylsulfinyl-3-(pyridin-3-yl)naphthalen-2-ols 11β-hydroxylase Aldosterone Aldosterone synthase Animals Cytochrome P-450 CYP11B2 - antagonists & inhibitors Cytochrome P-450 CYP11B2 - metabolism Dose-Response Relationship, Drug Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - classification Enzyme Inhibitors - pharmacology Humans Male Models, Molecular Naphthols - chemical synthesis Naphthols - chemistry Naphthols - pharmacology Rats Rats, Wistar Selectivity Structure-Activity Relationship Sulfoxides - chemical synthesis Sulfoxides - chemistry Sulfoxides - pharmacology
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