Erythropoietin protects myocardium against ischemia–reperfusion injury under moderate hyperglycemia

Erythropoietin (EPO), an essential hormone for erythropoiesis, provides protection against myocardial ischemia/reperfusion (I/R) injury. Hyperglycemia during acute myocardial infarction aggravates organ damage and attenuates the efficacies of various protective measures. This study aimed to investig...

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Veröffentlicht in:	European journal of pharmacology 2014-12, Vol.745, p.1-9
Hauptverfasser:	Jun, Ji Hae, Jun, Na-Hyung, Shim, Jae-Kwang, Shin, Eun Jung, Kwak, Young-Lan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Animals Apoptosis Bcl-2 Cardioprotection Cardiotonic Agents - administration & dosage Cardiotonic Agents - metabolism Caspase 3 - metabolism Caspase-3 Cell Line Erythropoietin Erythropoietin - administration & dosage Erythropoietin - metabolism GATA binding protein-4 GATA4 Transcription Factor - metabolism Hyperglycemia Hyperglycemia - complications Hyperglycemia - metabolism Hyperglycemia - pathology Male MAP Kinase Signaling System - drug effects Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - pathology Myocardial Reperfusion Injury - prevention & control Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Phosphorylation Proto-Oncogene Proteins c-bcl-2 - metabolism Rats Rats, Sprague-Dawley Ubiquitination
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