Cigarette smoking and albuminuria are associated with impaired arterial smooth muscle function in patients with type 2 diabetes mellitus: a FIELD substudy
Abstract Aim Impaired arterial function has been implicated in diabetes-related atherosclerosis, but its determinants in high-risk adults have not been well characterised. We investigated factors associated with impaired arterial function in adults with type 2 diabetes. Methods Flow-mediated dilatat...
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| Veröffentlicht in: | Diabetes research and clinical practice 2014-11, Vol.106 (2), p.328-336 |
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| creator | Harmer, Jason A Keech, Anthony C Veillard, Anne-Sophie Skilton, Michael R Marwick, Thomas H Watts, Gerald F Meredith, Ian T Celermajer, David S |
| description | Abstract Aim Impaired arterial function has been implicated in diabetes-related atherosclerosis, but its determinants in high-risk adults have not been well characterised. We investigated factors associated with impaired arterial function in adults with type 2 diabetes. Methods Flow-mediated dilatation (a marker of endothelial function) and dilator response to glyceryl trinitrate (to assess smooth muscle function) of the brachial artery were assessed at baseline in 193 patients with type 2 diabetes from the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study. Traditional risk factors were assessed and a multivariable model was constructed to identify factors independently associated with impaired arterial function. Results Median age was 64 years (interquartile range, 58–69; 61% male) and duration of diabetes was 4 years (interquartile range, 2–9). Flow-mediated dilatation (3.06 ± 0.25%, mean ± SEM) was severely impaired but not significantly associated with other risk factors. Dilator responses to glyceryl trinitrate (10.56 ± 0.52%) were significantly and independently impaired in past and present cigarette smokers ( P = 0.005) and in subjects with increased urinary albumin/creatinine ratio ( P = 0.01). Conclusions In adults with type 2 diabetes and known or suspected atherosclerosis, arterial smooth muscle-dependent dilatation was shown to be significantly impaired in cigarette smokers and those with elevated urinary albumin levels. |
| doi_str_mv | 10.1016/j.diabres.2014.08.029 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1634723907</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0168822714003945</els_id><sourcerecordid>1634723907</sourcerecordid><originalsourceid>FETCH-LOGICAL-c420t-9c98e12335c7cc0395e8e4610c4359d0ee4c7466ec4c038724a4252b5743e80b3</originalsourceid><addsrcrecordid>eNqFUk2P0zAQtRCILQs_AeQjlwZ_NgkH0KrswkqVOABny3Gmi7uJEzw2qH-FX4tDCwcunGzrvTczfm8Iec5ZxRnfvDpUvbddBKwE46piTcVE-4CseFOLdSNE_ZCsCq_5fb8gTxAPjLGNVPoxuRBaMs6kXpGfW39nI6QEFMfp3oc7akNP7dDl0YccvaUFphZxct4m6OkPn75SP87Wx_KyMUEhDYt6KsCY0Q1A9zm45KdAfaCzTR5CwpMyHWeggi7DQwKkIwyDTxlfU0tvbq937yjmDlPuj0_Jo70dEJ6dz0vy5eb68_bDevfx_e32ard2SrC0bl3bABdSalc7x2SroQG14cwpqdueAShXq80GnCpocUdZJbTodK0kNKyTl-Tlqe4cp28ZMJnRoytj2QBTRsOLabWQLasLVZ-oLk6IEfZmjn608Wg4M0ss5mDOsZglFsMaU2IpuhfnFrkbof-r-pNDIbw9EaB89LuHaNAV0xz0xWWXTD_5_7Z4808FN_jgnR3u4Qh4mHIMxUXDDQrDzKdlN5bV4IoVz5SWvwCcKbes</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1634723907</pqid></control><display><type>article</type><title>Cigarette smoking and albuminuria are associated with impaired arterial smooth muscle function in patients with type 2 diabetes mellitus: a FIELD substudy</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Harmer, Jason A ; Keech, Anthony C ; Veillard, Anne-Sophie ; Skilton, Michael R ; Marwick, Thomas H ; Watts, Gerald F ; Meredith, Ian T ; Celermajer, David S</creator><creatorcontrib>Harmer, Jason A ; Keech, Anthony C ; Veillard, Anne-Sophie ; Skilton, Michael R ; Marwick, Thomas H ; Watts, Gerald F ; Meredith, Ian T ; Celermajer, David S ; for the FIELD Vascular Study Investigators ; FIELD Vascular Study Investigators</creatorcontrib><description>Abstract Aim Impaired arterial function has been implicated in diabetes-related atherosclerosis, but its determinants in high-risk adults have not been well characterised. We investigated factors associated with impaired arterial function in adults with type 2 diabetes. Methods Flow-mediated dilatation (a marker of endothelial function) and dilator response to glyceryl trinitrate (to assess smooth muscle function) of the brachial artery were assessed at baseline in 193 patients with type 2 diabetes from the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study. Traditional risk factors were assessed and a multivariable model was constructed to identify factors independently associated with impaired arterial function. Results Median age was 64 years (interquartile range, 58–69; 61% male) and duration of diabetes was 4 years (interquartile range, 2–9). Flow-mediated dilatation (3.06 ± 0.25%, mean ± SEM) was severely impaired but not significantly associated with other risk factors. Dilator responses to glyceryl trinitrate (10.56 ± 0.52%) were significantly and independently impaired in past and present cigarette smokers ( P = 0.005) and in subjects with increased urinary albumin/creatinine ratio ( P = 0.01). Conclusions In adults with type 2 diabetes and known or suspected atherosclerosis, arterial smooth muscle-dependent dilatation was shown to be significantly impaired in cigarette smokers and those with elevated urinary albumin levels.</description><identifier>ISSN: 0168-8227</identifier><identifier>EISSN: 1872-8227</identifier><identifier>DOI: 10.1016/j.diabres.2014.08.029</identifier><identifier>PMID: 25301035</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Aged ; Albuminuria - epidemiology ; Albuminuria - physiopathology ; Arterial function ; Atherosclerosis ; Brachial Artery - drug effects ; Brachial Artery - physiopathology ; Diabetes Mellitus, Type 2 - drug therapy ; Diabetes Mellitus, Type 2 - physiopathology ; Diabetic Angiopathies - complications ; Diabetic Angiopathies - epidemiology ; Endocrinology & Metabolism ; Endothelium, Vascular - drug effects ; Endothelium, Vascular - physiopathology ; Female ; Fenofibrate - therapeutic use ; Flow-mediated dilatation ; Glyceryl trinitrate ; Humans ; Hypolipidemic Agents - therapeutic use ; Male ; Middle Aged ; Muscle, Smooth, Vascular - drug effects ; Muscle, Smooth, Vascular - physiopathology ; Nitroglycerin - pharmacology ; Risk Factors ; Smoking - epidemiology ; Smoking - physiopathology ; Smooth muscle cell ; Type 2 diabetes mellitus ; Vasodilation - drug effects ; Vasodilation - physiology</subject><ispartof>Diabetes research and clinical practice, 2014-11, Vol.106 (2), p.328-336</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2014 Elsevier Ireland Ltd</rights><rights>Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-9c98e12335c7cc0395e8e4610c4359d0ee4c7466ec4c038724a4252b5743e80b3</citedby><cites>FETCH-LOGICAL-c420t-9c98e12335c7cc0395e8e4610c4359d0ee4c7466ec4c038724a4252b5743e80b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0168822714003945$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25301035$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Harmer, Jason A</creatorcontrib><creatorcontrib>Keech, Anthony C</creatorcontrib><creatorcontrib>Veillard, Anne-Sophie</creatorcontrib><creatorcontrib>Skilton, Michael R</creatorcontrib><creatorcontrib>Marwick, Thomas H</creatorcontrib><creatorcontrib>Watts, Gerald F</creatorcontrib><creatorcontrib>Meredith, Ian T</creatorcontrib><creatorcontrib>Celermajer, David S</creatorcontrib><creatorcontrib>for the FIELD Vascular Study Investigators</creatorcontrib><creatorcontrib>FIELD Vascular Study Investigators</creatorcontrib><title>Cigarette smoking and albuminuria are associated with impaired arterial smooth muscle function in patients with type 2 diabetes mellitus: a FIELD substudy</title><title>Diabetes research and clinical practice</title><addtitle>Diabetes Res Clin Pract</addtitle><description>Abstract Aim Impaired arterial function has been implicated in diabetes-related atherosclerosis, but its determinants in high-risk adults have not been well characterised. We investigated factors associated with impaired arterial function in adults with type 2 diabetes. Methods Flow-mediated dilatation (a marker of endothelial function) and dilator response to glyceryl trinitrate (to assess smooth muscle function) of the brachial artery were assessed at baseline in 193 patients with type 2 diabetes from the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study. Traditional risk factors were assessed and a multivariable model was constructed to identify factors independently associated with impaired arterial function. Results Median age was 64 years (interquartile range, 58–69; 61% male) and duration of diabetes was 4 years (interquartile range, 2–9). Flow-mediated dilatation (3.06 ± 0.25%, mean ± SEM) was severely impaired but not significantly associated with other risk factors. Dilator responses to glyceryl trinitrate (10.56 ± 0.52%) were significantly and independently impaired in past and present cigarette smokers ( P = 0.005) and in subjects with increased urinary albumin/creatinine ratio ( P = 0.01). Conclusions In adults with type 2 diabetes and known or suspected atherosclerosis, arterial smooth muscle-dependent dilatation was shown to be significantly impaired in cigarette smokers and those with elevated urinary albumin levels.</description><subject>Aged</subject><subject>Albuminuria - epidemiology</subject><subject>Albuminuria - physiopathology</subject><subject>Arterial function</subject><subject>Atherosclerosis</subject><subject>Brachial Artery - drug effects</subject><subject>Brachial Artery - physiopathology</subject><subject>Diabetes Mellitus, Type 2 - drug therapy</subject><subject>Diabetes Mellitus, Type 2 - physiopathology</subject><subject>Diabetic Angiopathies - complications</subject><subject>Diabetic Angiopathies - epidemiology</subject><subject>Endocrinology & Metabolism</subject><subject>Endothelium, Vascular - drug effects</subject><subject>Endothelium, Vascular - physiopathology</subject><subject>Female</subject><subject>Fenofibrate - therapeutic use</subject><subject>Flow-mediated dilatation</subject><subject>Glyceryl trinitrate</subject><subject>Humans</subject><subject>Hypolipidemic Agents - therapeutic use</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Muscle, Smooth, Vascular - drug effects</subject><subject>Muscle, Smooth, Vascular - physiopathology</subject><subject>Nitroglycerin - pharmacology</subject><subject>Risk Factors</subject><subject>Smoking - epidemiology</subject><subject>Smoking - physiopathology</subject><subject>Smooth muscle cell</subject><subject>Type 2 diabetes mellitus</subject><subject>Vasodilation - drug effects</subject><subject>Vasodilation - physiology</subject><issn>0168-8227</issn><issn>1872-8227</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUk2P0zAQtRCILQs_AeQjlwZ_NgkH0KrswkqVOABny3Gmi7uJEzw2qH-FX4tDCwcunGzrvTczfm8Iec5ZxRnfvDpUvbddBKwE46piTcVE-4CseFOLdSNE_ZCsCq_5fb8gTxAPjLGNVPoxuRBaMs6kXpGfW39nI6QEFMfp3oc7akNP7dDl0YccvaUFphZxct4m6OkPn75SP87Wx_KyMUEhDYt6KsCY0Q1A9zm45KdAfaCzTR5CwpMyHWeggi7DQwKkIwyDTxlfU0tvbq937yjmDlPuj0_Jo70dEJ6dz0vy5eb68_bDevfx_e32ard2SrC0bl3bABdSalc7x2SroQG14cwpqdueAShXq80GnCpocUdZJbTodK0kNKyTl-Tlqe4cp28ZMJnRoytj2QBTRsOLabWQLasLVZ-oLk6IEfZmjn608Wg4M0ss5mDOsZglFsMaU2IpuhfnFrkbof-r-pNDIbw9EaB89LuHaNAV0xz0xWWXTD_5_7Z4808FN_jgnR3u4Qh4mHIMxUXDDQrDzKdlN5bV4IoVz5SWvwCcKbes</recordid><startdate>20141101</startdate><enddate>20141101</enddate><creator>Harmer, Jason A</creator><creator>Keech, Anthony C</creator><creator>Veillard, Anne-Sophie</creator><creator>Skilton, Michael R</creator><creator>Marwick, Thomas H</creator><creator>Watts, Gerald F</creator><creator>Meredith, Ian T</creator><creator>Celermajer, David S</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20141101</creationdate><title>Cigarette smoking and albuminuria are associated with impaired arterial smooth muscle function in patients with type 2 diabetes mellitus: a FIELD substudy</title><author>Harmer, Jason A ; Keech, Anthony C ; Veillard, Anne-Sophie ; Skilton, Michael R ; Marwick, Thomas H ; Watts, Gerald F ; Meredith, Ian T ; Celermajer, David S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-9c98e12335c7cc0395e8e4610c4359d0ee4c7466ec4c038724a4252b5743e80b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Albuminuria - epidemiology</topic><topic>Albuminuria - physiopathology</topic><topic>Arterial function</topic><topic>Atherosclerosis</topic><topic>Brachial Artery - drug effects</topic><topic>Brachial Artery - physiopathology</topic><topic>Diabetes Mellitus, Type 2 - drug therapy</topic><topic>Diabetes Mellitus, Type 2 - physiopathology</topic><topic>Diabetic Angiopathies - complications</topic><topic>Diabetic Angiopathies - epidemiology</topic><topic>Endocrinology & Metabolism</topic><topic>Endothelium, Vascular - drug effects</topic><topic>Endothelium, Vascular - physiopathology</topic><topic>Female</topic><topic>Fenofibrate - therapeutic use</topic><topic>Flow-mediated dilatation</topic><topic>Glyceryl trinitrate</topic><topic>Humans</topic><topic>Hypolipidemic Agents - therapeutic use</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Muscle, Smooth, Vascular - drug effects</topic><topic>Muscle, Smooth, Vascular - physiopathology</topic><topic>Nitroglycerin - pharmacology</topic><topic>Risk Factors</topic><topic>Smoking - epidemiology</topic><topic>Smoking - physiopathology</topic><topic>Smooth muscle cell</topic><topic>Type 2 diabetes mellitus</topic><topic>Vasodilation - drug effects</topic><topic>Vasodilation - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Harmer, Jason A</creatorcontrib><creatorcontrib>Keech, Anthony C</creatorcontrib><creatorcontrib>Veillard, Anne-Sophie</creatorcontrib><creatorcontrib>Skilton, Michael R</creatorcontrib><creatorcontrib>Marwick, Thomas H</creatorcontrib><creatorcontrib>Watts, Gerald F</creatorcontrib><creatorcontrib>Meredith, Ian T</creatorcontrib><creatorcontrib>Celermajer, David S</creatorcontrib><creatorcontrib>for the FIELD Vascular Study Investigators</creatorcontrib><creatorcontrib>FIELD Vascular Study Investigators</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes research and clinical practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Harmer, Jason A</au><au>Keech, Anthony C</au><au>Veillard, Anne-Sophie</au><au>Skilton, Michael R</au><au>Marwick, Thomas H</au><au>Watts, Gerald F</au><au>Meredith, Ian T</au><au>Celermajer, David S</au><aucorp>for the FIELD Vascular Study Investigators</aucorp><aucorp>FIELD Vascular Study Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cigarette smoking and albuminuria are associated with impaired arterial smooth muscle function in patients with type 2 diabetes mellitus: a FIELD substudy</atitle><jtitle>Diabetes research and clinical practice</jtitle><addtitle>Diabetes Res Clin Pract</addtitle><date>2014-11-01</date><risdate>2014</risdate><volume>106</volume><issue>2</issue><spage>328</spage><epage>336</epage><pages>328-336</pages><issn>0168-8227</issn><eissn>1872-8227</eissn><abstract>Abstract Aim Impaired arterial function has been implicated in diabetes-related atherosclerosis, but its determinants in high-risk adults have not been well characterised. We investigated factors associated with impaired arterial function in adults with type 2 diabetes. Methods Flow-mediated dilatation (a marker of endothelial function) and dilator response to glyceryl trinitrate (to assess smooth muscle function) of the brachial artery were assessed at baseline in 193 patients with type 2 diabetes from the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study. Traditional risk factors were assessed and a multivariable model was constructed to identify factors independently associated with impaired arterial function. Results Median age was 64 years (interquartile range, 58–69; 61% male) and duration of diabetes was 4 years (interquartile range, 2–9). Flow-mediated dilatation (3.06 ± 0.25%, mean ± SEM) was severely impaired but not significantly associated with other risk factors. Dilator responses to glyceryl trinitrate (10.56 ± 0.52%) were significantly and independently impaired in past and present cigarette smokers ( P = 0.005) and in subjects with increased urinary albumin/creatinine ratio ( P = 0.01). Conclusions In adults with type 2 diabetes and known or suspected atherosclerosis, arterial smooth muscle-dependent dilatation was shown to be significantly impaired in cigarette smokers and those with elevated urinary albumin levels.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>25301035</pmid><doi>10.1016/j.diabres.2014.08.029</doi><tpages>9</tpages></addata></record> |
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| ispartof | Diabetes research and clinical practice, 2014-11, Vol.106 (2), p.328-336 |
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| subjects | Aged Albuminuria - epidemiology Albuminuria - physiopathology Arterial function Atherosclerosis Brachial Artery - drug effects Brachial Artery - physiopathology Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - physiopathology Diabetic Angiopathies - complications Diabetic Angiopathies - epidemiology Endocrinology & Metabolism Endothelium, Vascular - drug effects Endothelium, Vascular - physiopathology Female Fenofibrate - therapeutic use Flow-mediated dilatation Glyceryl trinitrate Humans Hypolipidemic Agents - therapeutic use Male Middle Aged Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - physiopathology Nitroglycerin - pharmacology Risk Factors Smoking - epidemiology Smoking - physiopathology Smooth muscle cell Type 2 diabetes mellitus Vasodilation - drug effects Vasodilation - physiology |
| title | Cigarette smoking and albuminuria are associated with impaired arterial smooth muscle function in patients with type 2 diabetes mellitus: a FIELD substudy |
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