Isolated adult lymphadenopathy: a rare presentation of Langerhans cell histiocytosis
Abstract Intro Langerhans cell histiocytosis (LCH) is a rare disease involving the proliferation of histiocytes in one or more organ systems. The presentation of LCH is more common in the pediatric population and rarely occurs within the adult population. Isolated lymph node involvement is an extrem...
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| Veröffentlicht in: | American journal of otolaryngology 2015-01, Vol.36 (1), p.103-105 |
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| container_title | American journal of otolaryngology |
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| creator | Melzer, Jonathan M., MD, LT, MC, USN Winters, Jessica, BS, ENS, MC, USN Mitchell, Allen O., MD, CAPT, MC, USN |
| description | Abstract Intro Langerhans cell histiocytosis (LCH) is a rare disease involving the proliferation of histiocytes in one or more organ systems. The presentation of LCH is more common in the pediatric population and rarely occurs within the adult population. Isolated lymph node involvement is an extremely rare presentation of the disease. The authors present a case of isolated lymph node LCH in an otherwise healthy adult female and discuss management strategies for these unusual findings. Methods A case report of a patient at a tertiary care facility in June 2014 is discussed. Results/Discussion The diagnosis, clinical course, and management strategies for isolated adult LCH are discussed and reviewed. Conclusion Langerhans cell histiocytosis rarely presents with isolated lymph node involvement in adults. Management and surveillance algorithms are discussed in this unusual case of seemingly benign lymphadenopathy. |
| doi_str_mv | 10.1016/j.amjoto.2014.10.016 |
| format | Article |
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The presentation of LCH is more common in the pediatric population and rarely occurs within the adult population. Isolated lymph node involvement is an extremely rare presentation of the disease. The authors present a case of isolated lymph node LCH in an otherwise healthy adult female and discuss management strategies for these unusual findings. Methods A case report of a patient at a tertiary care facility in June 2014 is discussed. Results/Discussion The diagnosis, clinical course, and management strategies for isolated adult LCH are discussed and reviewed. Conclusion Langerhans cell histiocytosis rarely presents with isolated lymph node involvement in adults. Management and surveillance algorithms are discussed in this unusual case of seemingly benign lymphadenopathy.</description><identifier>ISSN: 0196-0709</identifier><identifier>EISSN: 1532-818X</identifier><identifier>DOI: 10.1016/j.amjoto.2014.10.016</identifier><identifier>PMID: 25459314</identifier><identifier>CODEN: AJOTDP</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Biopsy ; Diagnosis, Differential ; Family medical history ; Female ; Histiocytosis, Langerhans-Cell - diagnosis ; Humans ; Liver ; Lymphatic Diseases - diagnosis ; Lymphatic system ; Mortality ; Otolaryngology ; Pediatrics ; Skin ; Surgery ; Ultrasonic imaging ; Young Adult</subject><ispartof>American journal of otolaryngology, 2015-01, Vol.36 (1), p.103-105</ispartof><rights>2015</rights><rights>Published by Elsevier Inc.</rights><rights>Copyright Elsevier Limited 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c515t-1e151202ea3f7099bc2d793b3e9ad93d3b13560090870676bf1b216a6ce048483</citedby><cites>FETCH-LOGICAL-c515t-1e151202ea3f7099bc2d793b3e9ad93d3b13560090870676bf1b216a6ce048483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.amjoto.2014.10.016$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25459314$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Melzer, Jonathan M., MD, LT, MC, USN</creatorcontrib><creatorcontrib>Winters, Jessica, BS, ENS, MC, USN</creatorcontrib><creatorcontrib>Mitchell, Allen O., MD, CAPT, MC, USN</creatorcontrib><title>Isolated adult lymphadenopathy: a rare presentation of Langerhans cell histiocytosis</title><title>American journal of otolaryngology</title><addtitle>Am J Otolaryngol</addtitle><description>Abstract Intro Langerhans cell histiocytosis (LCH) is a rare disease involving the proliferation of histiocytes in one or more organ systems. The presentation of LCH is more common in the pediatric population and rarely occurs within the adult population. Isolated lymph node involvement is an extremely rare presentation of the disease. The authors present a case of isolated lymph node LCH in an otherwise healthy adult female and discuss management strategies for these unusual findings. Methods A case report of a patient at a tertiary care facility in June 2014 is discussed. Results/Discussion The diagnosis, clinical course, and management strategies for isolated adult LCH are discussed and reviewed. Conclusion Langerhans cell histiocytosis rarely presents with isolated lymph node involvement in adults. Management and surveillance algorithms are discussed in this unusual case of seemingly benign lymphadenopathy.</description><subject>Biopsy</subject><subject>Diagnosis, Differential</subject><subject>Family medical history</subject><subject>Female</subject><subject>Histiocytosis, Langerhans-Cell - diagnosis</subject><subject>Humans</subject><subject>Liver</subject><subject>Lymphatic Diseases - diagnosis</subject><subject>Lymphatic system</subject><subject>Mortality</subject><subject>Otolaryngology</subject><subject>Pediatrics</subject><subject>Skin</subject><subject>Surgery</subject><subject>Ultrasonic imaging</subject><subject>Young Adult</subject><issn>0196-0709</issn><issn>1532-818X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2r1DAUxYMovnH0PxApuHHT8d4k_XIhyMOPBwMufIK7kKa3TmqnqUkq9L83ZZ4Kb-MqcHLuycnvMvYc4YCA5evhoM-Di-7AAWWSDkl8wHZYCJ7XWH97yHaATZlDBc0VexLCAABCiuIxu-KFLBqBcsdub4IbdaQu090yxmxcz_NJdzS5WcfT-ibTmdeestlToCnqaN2UuT476uk7-ZOeQmZoHLOTDenKrNEFG56yR70eAz27O_fs64f3t9ef8uPnjzfX7465KbCIORIWyIGTFn0q2bSGd1UjWkGN7hrRiRZFUQI0UFdQVmXbY8ux1KUhkLWsxZ69uuTO3v1cKER1tmGroydyS1BYCllxgSVP1pf3rINb_JTabS6QgmMismfy4jLeheCpV7O3Z-1XhaA26mpQF-pqo76pSUxjL-7Cl_ZM3d-hP5iT4e3FQInGL0teBWNpMtRZTyaqztn_vXA_wIx2skaPP2il8O8vKnAF6su2-W3xKAG45JX4DZLmqPk</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Melzer, Jonathan M., MD, LT, MC, USN</creator><creator>Winters, Jessica, BS, ENS, MC, USN</creator><creator>Mitchell, Allen O., MD, CAPT, MC, USN</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20150101</creationdate><title>Isolated adult lymphadenopathy: a rare presentation of Langerhans cell histiocytosis</title><author>Melzer, Jonathan M., MD, LT, MC, USN ; Winters, Jessica, BS, ENS, MC, USN ; Mitchell, Allen O., MD, CAPT, MC, USN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c515t-1e151202ea3f7099bc2d793b3e9ad93d3b13560090870676bf1b216a6ce048483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Biopsy</topic><topic>Diagnosis, Differential</topic><topic>Family medical history</topic><topic>Female</topic><topic>Histiocytosis, Langerhans-Cell - diagnosis</topic><topic>Humans</topic><topic>Liver</topic><topic>Lymphatic Diseases - diagnosis</topic><topic>Lymphatic system</topic><topic>Mortality</topic><topic>Otolaryngology</topic><topic>Pediatrics</topic><topic>Skin</topic><topic>Surgery</topic><topic>Ultrasonic imaging</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Melzer, Jonathan M., MD, LT, MC, USN</creatorcontrib><creatorcontrib>Winters, Jessica, BS, ENS, MC, USN</creatorcontrib><creatorcontrib>Mitchell, Allen O., MD, CAPT, MC, USN</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of otolaryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Melzer, Jonathan M., MD, LT, MC, USN</au><au>Winters, Jessica, BS, ENS, MC, USN</au><au>Mitchell, Allen O., MD, CAPT, MC, USN</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Isolated adult lymphadenopathy: a rare presentation of Langerhans cell histiocytosis</atitle><jtitle>American journal of otolaryngology</jtitle><addtitle>Am J Otolaryngol</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>36</volume><issue>1</issue><spage>103</spage><epage>105</epage><pages>103-105</pages><issn>0196-0709</issn><eissn>1532-818X</eissn><coden>AJOTDP</coden><abstract>Abstract Intro Langerhans cell histiocytosis (LCH) is a rare disease involving the proliferation of histiocytes in one or more organ systems. The presentation of LCH is more common in the pediatric population and rarely occurs within the adult population. Isolated lymph node involvement is an extremely rare presentation of the disease. The authors present a case of isolated lymph node LCH in an otherwise healthy adult female and discuss management strategies for these unusual findings. Methods A case report of a patient at a tertiary care facility in June 2014 is discussed. Results/Discussion The diagnosis, clinical course, and management strategies for isolated adult LCH are discussed and reviewed. Conclusion Langerhans cell histiocytosis rarely presents with isolated lymph node involvement in adults. Management and surveillance algorithms are discussed in this unusual case of seemingly benign lymphadenopathy.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>25459314</pmid><doi>10.1016/j.amjoto.2014.10.016</doi><tpages>3</tpages></addata></record> |
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| subjects | Biopsy Diagnosis, Differential Family medical history Female Histiocytosis, Langerhans-Cell - diagnosis Humans Liver Lymphatic Diseases - diagnosis Lymphatic system Mortality Otolaryngology Pediatrics Skin Surgery Ultrasonic imaging Young Adult |
| title | Isolated adult lymphadenopathy: a rare presentation of Langerhans cell histiocytosis |
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