Pulmonary overexpression of inhibitor κBα decreases the severity of ventilator-induced lung injury in a rat model

Activation of the nuclear factor-κB (NF-κB) pathway is central to the pathogenesis of lung injury and inflammation. We determined whether targeted overexpression of inhibitor-κBα (IκBα) in the lung could decrease the severity of ventilator-induced lung injury (VILI). Anaesthetized adult male Sprague...

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Veröffentlicht in:	British journal of anaesthesia : BJA 2014-12, Vol.113 (6), p.1046-1054
Hauptverfasser:	Hayes, M., Curley, G.F., Masterson, C., Contreras, M., Ansari, B., Devaney, J., O'Toole, D., Laffey, J.G.
Format:	Artikel
Sprache:	eng
Schlagworte:	acute respiratory distress syndrome Animals Dependovirus - genetics Disease Models, Animal Gene Expression gene therapy, somatic, ventilation, mechanical Genetic Therapy - methods Genetic Vectors I-kappa B Proteins - biosynthesis I-kappa B Proteins - genetics Lung - metabolism Male NF-kappa B - metabolism NF-KappaB Inhibitor alpha nuclear factor κ-B Oxygen - blood Pneumonia - metabolism Pneumonia - prevention & control Rats, Sprague-Dawley Respiration, Artificial - methods Survival Analysis Transgenes Ventilator-Induced Lung Injury - metabolism Ventilator-Induced Lung Injury - pathology Ventilator-Induced Lung Injury - prevention & control
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