Successful Antemortem Diagnosis and Treatment of Pulmonary Tumor Thrombotic Microangiopathy
Pulmonary tumor thrombotic microangiopathy (PTTM) is a fatal cancer-related complication with rapid progression. Although the underlying molecular mechanisms of PTTM remain unclear, platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) may play important roles in the pa...
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| Veröffentlicht in: | Internal Medicine 2014, Vol.53(22), pp.2595-2599 |
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| container_title | Internal Medicine |
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| creator | Higo, Kenjuro Kubota, Kayoko Takeda, Ayano Higashi, Michiyo Ohishi, Mitsuru |
| description | Pulmonary tumor thrombotic microangiopathy (PTTM) is a fatal cancer-related complication with rapid progression. Although the underlying molecular mechanisms of PTTM remain unclear, platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) may play important roles in the pathogenesis of PTTM. We herein report a case of PTTM that was diagnosed antemortem by pathology using pulmonary wedge aspiration. The patient was treated with a combination therapy of imatinib (PDGF receptor antagonist), bevacizumab (VEGF receptor inhibitor), S-1, and cisplatin. These findings suggest that molecular-target drugs are effective for the treatment of PTTM. |
| doi_str_mv | 10.2169/internalmedicine.53.2379 |
| format | Article |
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Med.</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>53</volume><issue>22</issue><spage>2595</spage><epage>2599</epage><pages>2595-2599</pages><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>Pulmonary tumor thrombotic microangiopathy (PTTM) is a fatal cancer-related complication with rapid progression. Although the underlying molecular mechanisms of PTTM remain unclear, platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) may play important roles in the pathogenesis of PTTM. We herein report a case of PTTM that was diagnosed antemortem by pathology using pulmonary wedge aspiration. The patient was treated with a combination therapy of imatinib (PDGF receptor antagonist), bevacizumab (VEGF receptor inhibitor), S-1, and cisplatin. 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| ispartof | Internal Medicine, 2014, Vol.53(22), pp.2595-2599 |
| issn | 0918-2918 1349-7235 |
| language | eng |
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| source | J-STAGE Free; MEDLINE |
| subjects | Angiogenesis Inhibitors - therapeutic use Antibodies, Monoclonal, Humanized - therapeutic use Antineoplastic Combined Chemotherapy Protocols - therapeutic use Autopsy Bevacizumab Colorectal Neoplasms - pathology Humans imatinib Lung Neoplasms - diagnosis Lung Neoplasms - drug therapy Lung Neoplasms - secondary Male Middle Aged pulmonary hypertension pulmonary tumor thrombotic microangiopathy Thrombotic Microangiopathies - diagnosis Thrombotic Microangiopathies - drug therapy Vascular Endothelial Growth Factor A - metabolism |
| title | Successful Antemortem Diagnosis and Treatment of Pulmonary Tumor Thrombotic Microangiopathy |
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