Isolation and Structure Elucidation of a New Metabolite Produced by Aspergillus parasiticus
A new metabolite, 1,3,6,8-tetrahydroxy-2-(1‘-hydroxy-3‘-oxobutyl)-anthraquinone, designated as asparasone A (1), was isolated from an Aspergillus parasiticus mutant (ATCC 20979), and its structure was deduced from spectral data. Several wild-type isolates of A. parasiticus also produced 1. Asparason...
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| Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 1997-08, Vol.60 (8), p.847-850 |
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| container_title | Journal of natural products (Washington, D.C.) |
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| creator | Sobolev, Victor S Cole, Richard J Dorner, Joe W Horn, Bruce W Harrigan, George G Gloer, James B |
| description | A new metabolite, 1,3,6,8-tetrahydroxy-2-(1‘-hydroxy-3‘-oxobutyl)-anthraquinone, designated as asparasone A (1), was isolated from an Aspergillus parasiticus mutant (ATCC 20979), and its structure was deduced from spectral data. Several wild-type isolates of A. parasiticus also produced 1. Asparasone A (1) is structurally related to intermediates in the aflatoxin biosynthetic pathway. |
| doi_str_mv | 10.1021/np970131m |
| format | Article |
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Several wild-type isolates of A. parasiticus also produced 1. Asparasone A (1) is structurally related to intermediates in the aflatoxin biosynthetic pathway.</description><identifier>ISSN: 0163-3864</identifier><identifier>EISSN: 1520-6025</identifier><identifier>DOI: 10.1021/np970131m</identifier><identifier>CODEN: JNPRDF</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>AFLATOXINAS ; AFLATOXINE ; AFLATOXINS ; Analytical, structural and metabolic biochemistry ; Aromatic and heterocyclic compounds ; ASPERGILLUS PARASITICUS ; BIOCHEMICAL PATHWAYS ; Biological and medical sciences ; BIOSINTESIS ; BIOSYNTHESE ; BIOSYNTHESIS ; CHEMICAL COMPOSITION ; CHEMICAL STRUCTURE ; COMPOSICION QUIMICA ; COMPOSITION CHIMIQUE ; ESPECTROMETRIA ; ESTRUCTURA QUIMICA ; Fundamental and applied biological sciences. Psychology ; GENETIC VARIATION ; Heterocyclic compounds, pigments ; METABOLITE ; METABOLITES ; METABOLITOS ; MUTANT ; MUTANTES ; MUTANTS ; Other biological molecules ; PRECURSORS ; SECONDARY METABOLITES ; SPECTRAL ANALYSIS ; SPECTROMETRIE ; SPECTROMETRY ; STRUCTURE CHIMIQUE ; VARIACION GENETICA ; VARIATION GENETIQUE ; VIA BIOQUIMICA DEL METABOLISMO ; VOIE BIOCHIMIQUE DU METABOLISME ; WILD STRAINS</subject><ispartof>Journal of natural products (Washington, D.C.), 1997-08, Vol.60 (8), p.847-850</ispartof><rights>Copyright © 1997 American Chemical Society and American Society of Pharmacognosy</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a443t-29cccf898053afd0359c4861f9080b4c5ea3bcbb3bd817940ec0977f6cf450cc3</citedby><cites>FETCH-LOGICAL-a443t-29cccf898053afd0359c4861f9080b4c5ea3bcbb3bd817940ec0977f6cf450cc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/np970131m$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/np970131m$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>315,781,785,2766,27078,27926,27927,56740,56790</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2787392$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Sobolev, Victor S</creatorcontrib><creatorcontrib>Cole, Richard J</creatorcontrib><creatorcontrib>Dorner, Joe W</creatorcontrib><creatorcontrib>Horn, Bruce W</creatorcontrib><creatorcontrib>Harrigan, George G</creatorcontrib><creatorcontrib>Gloer, James B</creatorcontrib><title>Isolation and Structure Elucidation of a New Metabolite Produced by Aspergillus parasiticus</title><title>Journal of natural products (Washington, D.C.)</title><addtitle>J. Nat. Prod</addtitle><description>A new metabolite, 1,3,6,8-tetrahydroxy-2-(1‘-hydroxy-3‘-oxobutyl)-anthraquinone, designated as asparasone A (1), was isolated from an Aspergillus parasiticus mutant (ATCC 20979), and its structure was deduced from spectral data. Several wild-type isolates of A. parasiticus also produced 1. Asparasone A (1) is structurally related to intermediates in the aflatoxin biosynthetic pathway.</description><subject>AFLATOXINAS</subject><subject>AFLATOXINE</subject><subject>AFLATOXINS</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Aromatic and heterocyclic compounds</subject><subject>ASPERGILLUS PARASITICUS</subject><subject>BIOCHEMICAL PATHWAYS</subject><subject>Biological and medical sciences</subject><subject>BIOSINTESIS</subject><subject>BIOSYNTHESE</subject><subject>BIOSYNTHESIS</subject><subject>CHEMICAL COMPOSITION</subject><subject>CHEMICAL STRUCTURE</subject><subject>COMPOSICION QUIMICA</subject><subject>COMPOSITION CHIMIQUE</subject><subject>ESPECTROMETRIA</subject><subject>ESTRUCTURA QUIMICA</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GENETIC VARIATION</subject><subject>Heterocyclic compounds, pigments</subject><subject>METABOLITE</subject><subject>METABOLITES</subject><subject>METABOLITOS</subject><subject>MUTANT</subject><subject>MUTANTES</subject><subject>MUTANTS</subject><subject>Other biological molecules</subject><subject>PRECURSORS</subject><subject>SECONDARY METABOLITES</subject><subject>SPECTRAL ANALYSIS</subject><subject>SPECTROMETRIE</subject><subject>SPECTROMETRY</subject><subject>STRUCTURE CHIMIQUE</subject><subject>VARIACION GENETICA</subject><subject>VARIATION GENETIQUE</subject><subject>VIA BIOQUIMICA DEL METABOLISMO</subject><subject>VOIE BIOCHIMIQUE DU METABOLISME</subject><subject>WILD STRAINS</subject><issn>0163-3864</issn><issn>1520-6025</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNptkMFu1DAQhi0EEkvhwAMg-QBIPQTs2IntY1taqFRgpW25cLAmE7ty8cbBTgR9e1Kl2hMnH_5vvvH8hLzm7ANnNf84jEYxLvj-CdnwpmZVy-rmKdkw3opK6FY-Jy9KuWOMCWaaDfl5WVKEKaSBwtDT3ZRnnObs6HmcMfRrkjwF-s39oV_dBF2KYXJ0m1M_o-tpd09PyujybYhxLnSEDCVMAefykjzzEIt79fgekZuL8-uzL9XV98-XZydXFUgppqo2iOi10awR4HsmGoNSt9wbplknsXEgOuw60fWaKyOZQ2aU8i162TBEcUTer94xp9-zK5Pdh4IuRhhcmotdTpdS1WoBj1cQcyolO2_HHPaQ7y1n9qE-e6hvYd8-SqEgRJ9hwFAOA7XSSph6waoVC2Vyfw8x5F-2VUI19nq7szu9VfpU_rCfFv7NyntIFm7zorzZcbNsbaTWD753aw5Y7F2a87A095_v_QOCQ5QP</recordid><startdate>19970801</startdate><enddate>19970801</enddate><creator>Sobolev, Victor S</creator><creator>Cole, Richard J</creator><creator>Dorner, Joe W</creator><creator>Horn, Bruce W</creator><creator>Harrigan, George G</creator><creator>Gloer, James B</creator><general>American Chemical Society</general><general>American Society of Pharmacognosy</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>M7N</scope><scope>P64</scope></search><sort><creationdate>19970801</creationdate><title>Isolation and Structure Elucidation of a New Metabolite Produced by Aspergillus parasiticus</title><author>Sobolev, Victor S ; Cole, Richard J ; Dorner, Joe W ; Horn, Bruce W ; Harrigan, George G ; Gloer, James B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a443t-29cccf898053afd0359c4861f9080b4c5ea3bcbb3bd817940ec0977f6cf450cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>AFLATOXINAS</topic><topic>AFLATOXINE</topic><topic>AFLATOXINS</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Aromatic and heterocyclic compounds</topic><topic>ASPERGILLUS PARASITICUS</topic><topic>BIOCHEMICAL PATHWAYS</topic><topic>Biological and medical sciences</topic><topic>BIOSINTESIS</topic><topic>BIOSYNTHESE</topic><topic>BIOSYNTHESIS</topic><topic>CHEMICAL COMPOSITION</topic><topic>CHEMICAL STRUCTURE</topic><topic>COMPOSICION QUIMICA</topic><topic>COMPOSITION CHIMIQUE</topic><topic>ESPECTROMETRIA</topic><topic>ESTRUCTURA QUIMICA</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GENETIC VARIATION</topic><topic>Heterocyclic compounds, pigments</topic><topic>METABOLITE</topic><topic>METABOLITES</topic><topic>METABOLITOS</topic><topic>MUTANT</topic><topic>MUTANTES</topic><topic>MUTANTS</topic><topic>Other biological molecules</topic><topic>PRECURSORS</topic><topic>SECONDARY METABOLITES</topic><topic>SPECTRAL ANALYSIS</topic><topic>SPECTROMETRIE</topic><topic>SPECTROMETRY</topic><topic>STRUCTURE CHIMIQUE</topic><topic>VARIACION GENETICA</topic><topic>VARIATION GENETIQUE</topic><topic>VIA BIOQUIMICA DEL METABOLISMO</topic><topic>VOIE BIOCHIMIQUE DU METABOLISME</topic><topic>WILD STRAINS</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sobolev, Victor S</creatorcontrib><creatorcontrib>Cole, Richard J</creatorcontrib><creatorcontrib>Dorner, Joe W</creatorcontrib><creatorcontrib>Horn, Bruce W</creatorcontrib><creatorcontrib>Harrigan, George G</creatorcontrib><creatorcontrib>Gloer, James B</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of natural products (Washington, D.C.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sobolev, Victor S</au><au>Cole, Richard J</au><au>Dorner, Joe W</au><au>Horn, Bruce W</au><au>Harrigan, George G</au><au>Gloer, James B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Isolation and Structure Elucidation of a New Metabolite Produced by Aspergillus parasiticus</atitle><jtitle>Journal of natural products (Washington, D.C.)</jtitle><addtitle>J. Nat. Prod</addtitle><date>1997-08-01</date><risdate>1997</risdate><volume>60</volume><issue>8</issue><spage>847</spage><epage>850</epage><pages>847-850</pages><issn>0163-3864</issn><eissn>1520-6025</eissn><coden>JNPRDF</coden><abstract>A new metabolite, 1,3,6,8-tetrahydroxy-2-(1‘-hydroxy-3‘-oxobutyl)-anthraquinone, designated as asparasone A (1), was isolated from an Aspergillus parasiticus mutant (ATCC 20979), and its structure was deduced from spectral data. Several wild-type isolates of A. parasiticus also produced 1. Asparasone A (1) is structurally related to intermediates in the aflatoxin biosynthetic pathway.</abstract><cop>Washington, DC</cop><cop>Glendale, AZ</cop><pub>American Chemical Society</pub><doi>10.1021/np970131m</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0163-3864 |
| ispartof | Journal of natural products (Washington, D.C.), 1997-08, Vol.60 (8), p.847-850 |
| issn | 0163-3864 1520-6025 |
| language | eng |
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| source | American Chemical Society |
| subjects | AFLATOXINAS AFLATOXINE AFLATOXINS Analytical, structural and metabolic biochemistry Aromatic and heterocyclic compounds ASPERGILLUS PARASITICUS BIOCHEMICAL PATHWAYS Biological and medical sciences BIOSINTESIS BIOSYNTHESE BIOSYNTHESIS CHEMICAL COMPOSITION CHEMICAL STRUCTURE COMPOSICION QUIMICA COMPOSITION CHIMIQUE ESPECTROMETRIA ESTRUCTURA QUIMICA Fundamental and applied biological sciences. Psychology GENETIC VARIATION Heterocyclic compounds, pigments METABOLITE METABOLITES METABOLITOS MUTANT MUTANTES MUTANTS Other biological molecules PRECURSORS SECONDARY METABOLITES SPECTRAL ANALYSIS SPECTROMETRIE SPECTROMETRY STRUCTURE CHIMIQUE VARIACION GENETICA VARIATION GENETIQUE VIA BIOQUIMICA DEL METABOLISMO VOIE BIOCHIMIQUE DU METABOLISME WILD STRAINS |
| title | Isolation and Structure Elucidation of a New Metabolite Produced by Aspergillus parasiticus |
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