Isolation and Structure Elucidation of a New Metabolite Produced by Aspergillus parasiticus

A new metabolite, 1,3,6,8-tetrahydroxy-2-(1‘-hydroxy-3‘-oxobutyl)-anthraquinone, designated as asparasone A (1), was isolated from an Aspergillus parasiticus mutant (ATCC 20979), and its structure was deduced from spectral data. Several wild-type isolates of A. parasiticus also produced 1. Asparason...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 1997-08, Vol.60 (8), p.847-850
Hauptverfasser:	Sobolev, Victor S, Cole, Richard J, Dorner, Joe W, Horn, Bruce W, Harrigan, George G, Gloer, James B
Format:	Artikel
Sprache:	eng
Schlagworte:	AFLATOXINAS AFLATOXINE AFLATOXINS Analytical, structural and metabolic biochemistry Aromatic and heterocyclic compounds ASPERGILLUS PARASITICUS BIOCHEMICAL PATHWAYS Biological and medical sciences BIOSINTESIS BIOSYNTHESE BIOSYNTHESIS CHEMICAL COMPOSITION CHEMICAL STRUCTURE COMPOSICION QUIMICA COMPOSITION CHIMIQUE ESPECTROMETRIA ESTRUCTURA QUIMICA Fundamental and applied biological sciences. Psychology GENETIC VARIATION Heterocyclic compounds, pigments METABOLITE METABOLITES METABOLITOS MUTANT MUTANTES MUTANTS Other biological molecules PRECURSORS SECONDARY METABOLITES SPECTRAL ANALYSIS SPECTROMETRIE SPECTROMETRY STRUCTURE CHIMIQUE VARIACION GENETICA VARIATION GENETIQUE VIA BIOQUIMICA DEL METABOLISMO VOIE BIOCHIMIQUE DU METABOLISME WILD STRAINS
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Beschreibung
Zusammenfassung:	A new metabolite, 1,3,6,8-tetrahydroxy-2-(1‘-hydroxy-3‘-oxobutyl)-anthraquinone, designated as asparasone A (1), was isolated from an Aspergillus parasiticus mutant (ATCC 20979), and its structure was deduced from spectral data. Several wild-type isolates of A. parasiticus also produced 1. Asparasone A (1) is structurally related to intermediates in the aflatoxin biosynthetic pathway.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np970131m