Bioavailability of tobacco-specific N-nitrosamines to the snuff dipper
Use of supercritical carbon dioxide extraction in the analysis of smokeless tobacco for tobacco-specific N-nitrosamines revealed the presence of higher levels of 4-(methylnitros-amino)-l-(3-pyridyl)-l-butanone (NNK) than had been determined with conventional methods. Whether human saliva may be simi...
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| Veröffentlicht in: | Carcinogenesis (New York) 1992-05, Vol.13 (5), p.863-866 |
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| container_title | Carcinogenesis (New York) |
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| creator | Prokopczyk, Bogdan Wu, Ming Cox, Jonathan E. Hoffmann, Dietrich |
| description | Use of supercritical carbon dioxide extraction in the analysis of smokeless tobacco for tobacco-specific N-nitrosamines revealed the presence of higher levels of 4-(methylnitros-amino)-l-(3-pyridyl)-l-butanone (NNK) than had been determined with conventional methods. Whether human saliva may be similarly capable of releasing apparently bound NNK during chewing or snuff dipping was tested by incubating smokeless tobacco with enzymatkally active saliva and with heat-treated saliva respectively. Enzymatkally active human saliva was found to liberate up to twice the amount of the highly carcinogenic NNK than did heat-treated saliva. This is of major consequence for the cancer risk assessment of snuff dippers and tobacco chewers. |
| doi_str_mv | 10.1093/carcin/13.5.863 |
| format | Article |
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Whether human saliva may be similarly capable of releasing apparently bound NNK during chewing or snuff dipping was tested by incubating smokeless tobacco with enzymatkally active saliva and with heat-treated saliva respectively. Enzymatkally active human saliva was found to liberate up to twice the amount of the highly carcinogenic NNK than did heat-treated saliva. 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Whether human saliva may be similarly capable of releasing apparently bound NNK during chewing or snuff dipping was tested by incubating smokeless tobacco with enzymatkally active saliva and with heat-treated saliva respectively. Enzymatkally active human saliva was found to liberate up to twice the amount of the highly carcinogenic NNK than did heat-treated saliva. 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| fulltext | fulltext |
| identifier | ISSN: 0143-3334 |
| ispartof | Carcinogenesis (New York), 1992-05, Vol.13 (5), p.863-866 |
| issn | 0143-3334 1460-2180 |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy |
| subjects | Biological and medical sciences Biological Availability Carcinogens - isolation & purification Carcinogens - pharmacokinetics Medical sciences Nitrosamines - isolation & purification Nitrosamines - pharmacokinetics Plants, Toxic Saliva - enzymology Tobacco, Smokeless - chemistry Tobacco, tobacco smoking Toxicology |
| title | Bioavailability of tobacco-specific N-nitrosamines to the snuff dipper |
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