Consumption of PCB-contaminated Freshwater Fish and Shortened Menstrual Cycle Length

Highly contaminated Lake Ontario sport fish represent an important human dietary exposure to polychlorinated biphenyls (PCBs) and other toxic contaminants that may disrupt endocrine pathways. New York State Angler Cohort women interviewed by telephone in 1993 provided menstrual cycle length (n 2,223...

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Veröffentlicht in:American journal of epidemiology 1997-12, Vol.146 (11), p.955-960
Hauptverfasser: Mendola, Pauline, Buck, Germaine M., Sever, Lowell E., Zielezny, Maria, Vena, John E.
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container_end_page 960
container_issue 11
container_start_page 955
container_title American journal of epidemiology
container_volume 146
creator Mendola, Pauline
Buck, Germaine M.
Sever, Lowell E.
Zielezny, Maria
Vena, John E.
description Highly contaminated Lake Ontario sport fish represent an important human dietary exposure to polychlorinated biphenyls (PCBs) and other toxic contaminants that may disrupt endocrine pathways. New York State Angler Cohort women interviewed by telephone in 1993 provided menstrual cycle length (n 2,223). Fish consumption at cohort enrollment in 1991 was categorized by duration and frequency and was used to calculate a PCB exposure index. Multiple regression analyses identified significant cycle length reductions with consumption of more than one fish meal per month (1.11 days) and moderatelhigh estimated PCB index (−1.03 days). Women who consumed contaminated fish for 7 years or more also had shorter cycles (−0.63 days).
doi_str_mv 10.1093/oxfordjournals.aje.a009222
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source MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection
subjects Adolescent
Adult
Animals
Biological and medical sciences
Cohort Studies
Diet
environmental pollutants
Feeding Behavior
Female
Fishes
Food Contamination
Food toxicology
Freshwater
Humans
Medical sciences
Menstrual Cycle - drug effects
menstruation
New York
polychlorinated biphenyls
Polychlorinated Biphenyls - adverse effects
Regression Analysis
Toxicology
women
title Consumption of PCB-contaminated Freshwater Fish and Shortened Menstrual Cycle Length
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