Growth Hormone Signaling in Muscle and Adipose Tissue of Obese Human Subjects: Associations With Measures of Body Composition and Interaction With Resveratrol Treatment

Context: Growth hormone (GH) secretion is reduced in obesity, despite normal serum insulin-like growth factor I (IGF-1) levels, but the association between obesity and the GH signaling is unknown. Furthermore, SIRT1, an nicotinamide adenine dinucleotide–dependent protein deacetylase, reduces hepatic...

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