Proteome-Wide Discovery of Unknown ATP-Binding Proteins and Kinase Inhibitor Target Proteins Using an ATP Probe

ATP-binding proteins, including protein kinases, play essential roles in many biological and pathological processes and thus these proteins are attractive as drug targets. Acyl-ATP probes have been developed as efficient probes for kinase enrichment, and these probes have also been used to enrich ot...

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Veröffentlicht in:	Journal of proteome research 2014-12, Vol.13 (12), p.5461-5470
Hauptverfasser:	Adachi, Jun, Kishida, Marina, Watanabe, Shio, Hashimoto, Yuuki, Fukamizu, Kazuna, Tomonaga, Takeshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Amino Acid Sequence Binding Sites Binding, Competitive Carrier Proteins - metabolism Chromatography, Liquid HeLa Cells Humans Molecular Probes - metabolism Molecular Sequence Data Protein Binding Protein Kinase Inhibitors - metabolism Protein Kinase Inhibitors - pharmacology Protein Kinases - metabolism Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - metabolism Proteome - metabolism Proteomics - methods Pyrazoles - metabolism Pyrazoles - pharmacology Pyridines - metabolism Pyridines - pharmacology Staurosporine - metabolism Staurosporine - pharmacology Tandem Mass Spectrometry
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