Mia40 Combines Thiol Oxidase and Disulfide Isomerase Activity to Efficiently Catalyze Oxidative Folding in Mitochondria

Mia40 (a mitochondrial import and assembly protein) catalyzes disulfide bond formation in proteins in the mitochondrial intermembrane space. By using Cox17 (a mitochondrial copper-binding protein) as a natural substrate, we discovered that, in the presence of Mia40, the formation of native disulfide...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of molecular biology 2014-12, Vol.426 (24), p.4087-4098
Hauptverfasser:	Koch, Johanna R., Schmid, Franz X.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biocatalysis Cation Transport Proteins - chemistry Cation Transport Proteins - genetics Cation Transport Proteins - metabolism disulfide relay Disulfides - chemistry Disulfides - metabolism Electrophoresis, Polyacrylamide Gel Isomerism Kinetics mitochondrial disulfide formation mitochondrial import mitochondrial intermembrane space Mitochondrial Membrane Transport Proteins - genetics Mitochondrial Membrane Transport Proteins - metabolism Models, Molecular Molecular Chaperones - chemistry Molecular Chaperones - genetics Molecular Chaperones - metabolism Mutation, Missense Oxidation-Reduction oxidative protein folding Oxidoreductases - genetics Oxidoreductases - metabolism Protein Disulfide-Isomerases - genetics Protein Disulfide-Isomerases - metabolism Protein Folding Protein Structure, Secondary Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Substrate Specificity Sulfhydryl Compounds - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!