Prognostic impact of human leukocyte antigen class I expression and association of platinum resistance with immunologic profiles in epithelial ovarian cancer

Epithelial ovarian cancer (EOC) is one of the most deadly carcinomas in females. Immune systems can recognize EOCs; however, a defect of human leukocyte antigen (HLA) class I expression is known to be a major mechanism for escape from immune systems, resulting in poor prognosis. The purpose of this...

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Veröffentlicht in:	Cancer immunology research 2014-12, Vol.2 (12), p.1220-1229
Hauptverfasser:	Mariya, Tasuku, Hirohashi, Yoshihiko, Torigoe, Toshihiko, Asano, Takuya, Kuroda, Takafumi, Yasuda, Kazuyo, Mizuuchi, Masahito, Sonoda, Tomoko, Saito, Tsuyoshi, Sato, Noriyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Carcinoma, Ovarian Epithelial Drug Resistance, Neoplasm - genetics Female Gene Expression Regulation, Neoplastic Histocompatibility Antigens Class I - genetics Histocompatibility Antigens Class I - immunology Humans Middle Aged Neoplasm Metastasis Neoplasm Staging Neoplasms, Glandular and Epithelial - drug therapy Neoplasms, Glandular and Epithelial - genetics Neoplasms, Glandular and Epithelial - immunology Neoplasms, Glandular and Epithelial - mortality Neoplasms, Glandular and Epithelial - pathology Ovarian Neoplasms - drug therapy Ovarian Neoplasms - genetics Ovarian Neoplasms - immunology Ovarian Neoplasms - mortality Ovarian Neoplasms - pathology Platinum - pharmacology Platinum - therapeutic use Prognosis Risk Factors
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