Synthesis and biological evaluation of new BSH-conjugated chlorin derivatives as agents for both photodynamic therapy and boron neutron capture therapy of cancer

•Four new BSH-conjugated chlorin derivatives for both PDT and BNCT were synthesized.•The in vivo biodistribution and clearance of the four derivatives were investigated.•Two derivatives showed good tumor-selective accumulation.•Tumor growth was significantly inhibited by PDT using one of the derivat...

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Veröffentlicht in:Journal of photochemistry and photobiology. B, Biology Biology, 2014-11, Vol.140, p.140-149
Hauptverfasser: Asano, Ryuji, Nagami, Amon, Fukumoto, Yuki, Miura, Kaori, Yazama, Futoshi, Ito, Hideyuki, Sakata, Isao, Tai, Akihiro
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Sprache:eng
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