Immunization of colorectal cancer patients with modified ovine submaxillary gland mucin and adjuvants induces IgM and IgG antibodies to sialylated Tn

Tn and sialylated Tn (sTn) are blood group-related epitopes expressed on mucins of colon carcinoma and other epithelial tumors and are, therefore, potential targets for immunological control. We have immunized 20 colorectal cancer patients at high risk for recurrence with a vaccine consisting of par...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1992-10, Vol.52 (20), p.5663-5667
Hauptverfasser:	O'BOYLE, K. P, ZAMORE, R, ADLURI, S, COHEN, A, KEMENY, N, WELT, S, LLOYD, K. O, OETTGEN, H. F, OLD, L. J, LIVINGSTON, P. O
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - pharmacology Animals Antibody Specificity Antigens, Neoplasm - administration & dosage Antigens, Neoplasm - immunology Antigens, Tumor-Associated, Carbohydrate - administration & dosage Antigens, Tumor-Associated, Carbohydrate - immunology Antineoplastic agents Biological and medical sciences Colorectal Neoplasms - blood Colorectal Neoplasms - immunology Colorectal Neoplasms - therapy Humans Hypersensitivity, Delayed - immunology Immune Sera - analysis Immunoglobulin G - biosynthesis Immunoglobulin M - biosynthesis Immunotherapy Medical sciences Mucins - administration & dosage Mucins - immunology Pharmacology. Drug treatments Sheep Submandibular Gland - chemistry Vaccines - administration & dosage Vaccines - adverse effects Vaccines - immunology
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