Retinoic Acid Induces Apoptosis‐Associated Neural Differentiation of a Murine Teratocarcinoma Cell Line

: Incubation with all‐trans retinoic acid (RA) induces PCC7‐Mz1 embryonic carcinoma cells to cease proliferation and to develop into a tissue‐like pattern of neuronal, astroglial, and fibroblast‐like derivatives over a period of several days. Concomitant with the induction of differentiation by RA,...

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Veröffentlicht in:	Journal of neurochemistry 1998-01, Vol.70 (1), p.47-58
Hauptverfasser:	Herget, Thomas, Specht, Heike, Esdar, Christina, Oehrlein, Silke A., Maelicke, Alfred
Format:	Artikel
Sprache:	eng
Schlagworte:	Ageing, cell death Animals Apoptosis Apoptosis - physiology Biological and medical sciences Cell Differentiation - physiology Cell physiology Fundamental and applied biological sciences. Psychology GAP-43 Protein - metabolism Gene Expression Regulation - physiology Genes, bcl-2 - genetics Mice Molecular and cellular biology Neurogenesis Neurons - cytology Protein kinase C Protein Kinase C - physiology Retinoic acid Stem cells Teratocarcinoma - metabolism Teratocarcinoma - pathology Tretinoin - pharmacology Tumor Cells, Cultured - drug effects
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