Inhibitory effect of norcantharidin on K562 human myeloid leukemia cells in vitro
Mylabris, the dried body of the Chinese blister beetle, has been used as a Chinese medicinal for over 2000 years. Its active constituent, cantharidin, has antitumor properties and causes leukocytosis. Norcantharidin (NCTD), the demethylated form of cantharidin, is easier to synthesize and is less to...
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| Veröffentlicht in: | Leukemia research 1991, Vol.15 (10), p.883-886 |
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| creator | Yi, Shounan Wass, Jane Vincent, Paul Iland, Harry |
| description | Mylabris, the dried body of the Chinese blister beetle, has been used as a Chinese medicinal for over 2000 years. Its active constituent, cantharidin, has antitumor properties and causes leukocytosis. Norcantharidin (NCTD), the demethylated form of cantharidin, is easier to synthesize and is less toxic. NCTD irreversibly reduced the clonogenic efficiency of parental and drug-resistant K562 sublines, with drug-resistant sublines showing greater susceptibility to NCTD than parental cells. NCTD inhibited DNA synthesis by blocking cells at the G
2/M phase of the cell cycle. The data suggest that NCTD may be suitable in the treatment of drug-resistant leukemia. |
| doi_str_mv | 10.1016/0145-2126(91)90163-N |
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2/M phase of the cell cycle. The data suggest that NCTD may be suitable in the treatment of drug-resistant leukemia.</description><subject>Antineoplastic Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Bridged Bicyclo Compounds - pharmacology</subject><subject>Bridged Bicyclo Compounds, Heterocyclic</subject><subject>cell cycle</subject><subject>Cell Division - drug effects</subject><subject>cytotoxic</subject><subject>Depression, Chemical</subject><subject>Drug Resistance</subject><subject>Folic Acid Antagonists - pharmacology</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Interphase - drug effects</subject><subject>leukemia</subject><subject>Leukemia, Myeloid - pathology</subject><subject>Medical sciences</subject><subject>Methotrexate - pharmacology</subject><subject>Mitosis - drug effects</subject><subject>Norcantharidin</subject><subject>Pyrimidines - pharmacology</subject><subject>resistance</subject><subject>Tumor Cells, Cultured - drug effects</subject><subject>Tumor Cells, Cultured - pathology</subject><subject>Tumor Stem Cell Assay</subject><issn>0145-2126</issn><issn>1873-5835</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE2LFDEQhoMo67j6DxRyENFDa9JJepLLgix-LC4rgp5DdVJhot3JmnQvzL834wzrzVNBvc9bFA8hzzl7yxkf3jEuVdfzfnht-BvTNqK7eUA2XG9Fp7RQD8nmHnlMntT6kzGmDDdn5IybnkupN-TbVdrFMS657CmGgG6hOdCUi4O07KBEHxPNiX5RQ0936wyJznuccvR0wvUXzhGow2mqtHF3cSn5KXkUYKr47DTPyY-PH75ffu6uv366unx_3TmhxdJtGY4aeq22YpDcG60gaDV6aAHTzoPoDQgHKAcUIgwBRsEHI3scHVPBi3Py6nj3tuTfK9bFzrEeXoGEea22-eillKqB8gi6kmstGOxtiTOUveXMHkzagyZ70GQNt39N2ptWe3G6v44z-n-lo7qWvzzlUB1MoUBysd5jSiq5HVjDLo4YNhd3EYutLmJy6GNptq3P8f9__AGpSI8m</recordid><startdate>1991</startdate><enddate>1991</enddate><creator>Yi, Shounan</creator><creator>Wass, Jane</creator><creator>Vincent, Paul</creator><creator>Iland, Harry</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>1991</creationdate><title>Inhibitory effect of norcantharidin on K562 human myeloid leukemia cells in vitro</title><author>Yi, Shounan ; 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Its active constituent, cantharidin, has antitumor properties and causes leukocytosis. Norcantharidin (NCTD), the demethylated form of cantharidin, is easier to synthesize and is less toxic. NCTD irreversibly reduced the clonogenic efficiency of parental and drug-resistant K562 sublines, with drug-resistant sublines showing greater susceptibility to NCTD than parental cells. NCTD inhibited DNA synthesis by blocking cells at the G
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| ispartof | Leukemia research, 1991, Vol.15 (10), p.883-886 |
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| subjects | Antineoplastic Agents - pharmacology Biological and medical sciences Bridged Bicyclo Compounds - pharmacology Bridged Bicyclo Compounds, Heterocyclic cell cycle Cell Division - drug effects cytotoxic Depression, Chemical Drug Resistance Folic Acid Antagonists - pharmacology Hematologic and hematopoietic diseases Humans Interphase - drug effects leukemia Leukemia, Myeloid - pathology Medical sciences Methotrexate - pharmacology Mitosis - drug effects Norcantharidin Pyrimidines - pharmacology resistance Tumor Cells, Cultured - drug effects Tumor Cells, Cultured - pathology Tumor Stem Cell Assay |
| title | Inhibitory effect of norcantharidin on K562 human myeloid leukemia cells in vitro |
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