Changes in D2 but not D1 receptor binding in the striatum following a selective lesion of striatopallidal neurons

We have used the immunotoxin OX7/saporin, a suicide transport agent, to selectively lesion striatopallidal neurons. Following injection of OX7/saporin into the globus pallidus, in situ hybridization for preproenkephalin mRNA was examined in the striatum to confirm successful retrograde neurotoxicity...

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Veröffentlicht in:	Brain research 1992-09, Vol.590 (1-2), p.305-310
Hauptverfasser:	HARRISON, M. B, WILEY, R. G, WOOTEN, G. F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Corpus Striatum - cytology Corpus Striatum - drug effects Corpus Striatum - physiology Fundamental and applied biological sciences. Psychology Globus Pallidus - cytology Globus Pallidus - drug effects Globus Pallidus - physiology Immunotoxins In Situ Hybridization Male N-Glycosyl Hydrolases Neurons - metabolism Neurons - physiology Plant Proteins Rats Rats, Sprague-Dawley Receptors, Dopamine D1 - metabolism Receptors, Dopamine D2 - metabolism Ribosome Inactivating Proteins, Type 1 Saporins Vertebrates: nervous system and sense organs
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