An anti‐mucin immunotoxin BrE‐3‐ricin A‐chain is potently and selectively toxic to human small‐cell lung cancer

Monoclonal antibodies (MAbs) known to recognize epithelial mucin or defined carbohydrate structures present on mucin molecules were screened for their ability to form cytotoxic agents with ricin A‐chain active against human small‐cell lung cancer (SCLC) in an indirect assay of immunotoxin cytotoxici...

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Veröffentlicht in:	International journal of cancer 1992-10, Vol.52 (4), p.624-630
Hauptverfasser:	Derbyshire, Elaine J., Wawrzynczak, Edward J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - immunology Antineoplastic agents Biological and medical sciences Carcinoma, Small Cell - pathology Carcinoma, Small Cell - therapy Fluorescent Antibody Technique General aspects Humans Immunotoxins - pharmacology Lung Neoplasms - pathology Lung Neoplasms - therapy Medical sciences Mice Mucins - immunology Pharmacology. Drug treatments Ricin - pharmacology Tumor Cells, Cultured - drug effects
Online-Zugang:	Volltext
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