Hypoxia increases the susceptibility of pulmonary artery endothelial cells to hydrogen peroxide injury

The effect of hypoxia on subsequent susceptibility of porcine pulmonary artery endothelial cells (PAEC) to hydrogen peroxide (H2O2) injury was studied. Preexposure of PAEC to hypoxia for 3 or more h significantly increased susceptibility to subsequent H2O2 challenge. Analysis of the activities of an...

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Veröffentlicht in:	Journal of cellular physiology 1992-05, Vol.151 (2), p.228-238
Hauptverfasser:	Bhat, Ganesh B., Tinsley, Steven B., Tolson, J. Keith, Patel, Jawaharlal M., Block, Edward R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Amino Acids - metabolism Animals arteries Biological and medical sciences Cell physiology Cells, Cultured Culture Media Disease Susceptibility Effects of physical and chemical agents endothelium Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Endothelium, Vascular - pathology enhancement Fundamental and applied biological sciences. Psychology Glutathione - analogs & derivatives Glutathione - metabolism Glutathione Disulfide hydrogen peroxide Hydrogen Peroxide - metabolism Hydrogen Peroxide - pharmacology hypoxia Hypoxia - physiopathology induction injuries Molecular and cellular biology NAD - metabolism NADP - metabolism Oxidants - pharmacology pigs Pulmonary Artery - drug effects Pulmonary Artery - metabolism Pulmonary Artery - pathology
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