Determination of tetrahydrophtalimide and 2-thiothiazolidine-4-carboxylic acid, urinary metabolites of the fungicide captan, in rats and humans
Capillary gas chromatographic (GC) methods using sulphur and mass selective detection for the qualitative and quantitative determination of tetrahydrophtalimide (THPI) and 2-thiothiazolidine-4-carboxylic acid (TTCA), urinary metabolites of the fungicide captan in rat and humans, were developed. Urin...
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| Veröffentlicht in: | International archives of occupational and environmental health 1991-01, Vol.63 (3), p.181-186 |
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| container_title | International archives of occupational and environmental health |
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| creator | VAN WELIE, R. T. H VAN DUYN, P LAMME, E. K JÄGER, P VAN BAAR, B. L. M VERMEULEN, N. P. E |
| description | Capillary gas chromatographic (GC) methods using sulphur and mass selective detection for the qualitative and quantitative determination of tetrahydrophtalimide (THPI) and 2-thiothiazolidine-4-carboxylic acid (TTCA), urinary metabolites of the fungicide captan in rat and humans, were developed. Urinary detection limits were 2.7 micrograms/l for THPI and 110 micrograms/l for TTCA. Intraperitoneal and oral administration of captan to rats resulted in a 48-h cumulative urinary excretion of THPI of 1%-2% and 3%-9% of the dose, respectively. Cumulative urinary excretion of TTCA over 48 h ranged from 2% to 5% of the captan dose for the respective routes of administration. In urine of non-exposed human subjects, neither THPI nor TTCA could be detected. In urine of fruit-growers who were occupationally exposed to captan, both THPI and TTCA could be detected. Based on these results, THPI and TTCA are proposed as promising parameters for the biological monitoring of occupational exposure to captan. |
| doi_str_mv | 10.1007/BF00381566 |
| format | Article |
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T. H ; VAN DUYN, P ; LAMME, E. K ; JÄGER, P ; VAN BAAR, B. L. M ; VERMEULEN, N. P. E</creator><creatorcontrib>VAN WELIE, R. T. H ; VAN DUYN, P ; LAMME, E. K ; JÄGER, P ; VAN BAAR, B. L. M ; VERMEULEN, N. P. E</creatorcontrib><description>Capillary gas chromatographic (GC) methods using sulphur and mass selective detection for the qualitative and quantitative determination of tetrahydrophtalimide (THPI) and 2-thiothiazolidine-4-carboxylic acid (TTCA), urinary metabolites of the fungicide captan in rat and humans, were developed. Urinary detection limits were 2.7 micrograms/l for THPI and 110 micrograms/l for TTCA. Intraperitoneal and oral administration of captan to rats resulted in a 48-h cumulative urinary excretion of THPI of 1%-2% and 3%-9% of the dose, respectively. Cumulative urinary excretion of TTCA over 48 h ranged from 2% to 5% of the captan dose for the respective routes of administration. In urine of non-exposed human subjects, neither THPI nor TTCA could be detected. 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Based on these results, THPI and TTCA are proposed as promising parameters for the biological monitoring of occupational exposure to captan.</description><identifier>ISSN: 0340-0131</identifier><identifier>EISSN: 1432-1246</identifier><identifier>DOI: 10.1007/BF00381566</identifier><identifier>PMID: 1917068</identifier><identifier>CODEN: IAEHDW</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Agriculture ; Animals ; Biological and medical sciences ; Captan - toxicity ; Captan - urine ; Chromatography, Gas ; Environmental Monitoring - methods ; Humans ; Male ; Medical sciences ; Occupational Exposure ; Pesticides, fertilizers and other agrochemicals toxicology ; Phthalimides - urine ; Rats ; Rats, Inbred Strains ; Sulfur ; Thiazoles - urine ; Thiazolidines ; Toxicology</subject><ispartof>International archives of occupational and environmental health, 1991-01, Vol.63 (3), p.181-186</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342t-b4c4b77dded5843db9843df9db7b5351c0d24714620e93cf9848d58c884072e03</citedby><cites>FETCH-LOGICAL-c342t-b4c4b77dded5843db9843df9db7b5351c0d24714620e93cf9848d58c884072e03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4947853$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1917068$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>VAN WELIE, R. T. H</creatorcontrib><creatorcontrib>VAN DUYN, P</creatorcontrib><creatorcontrib>LAMME, E. K</creatorcontrib><creatorcontrib>JÄGER, P</creatorcontrib><creatorcontrib>VAN BAAR, B. L. M</creatorcontrib><creatorcontrib>VERMEULEN, N. P. E</creatorcontrib><title>Determination of tetrahydrophtalimide and 2-thiothiazolidine-4-carboxylic acid, urinary metabolites of the fungicide captan, in rats and humans</title><title>International archives of occupational and environmental health</title><addtitle>Int Arch Occup Environ Health</addtitle><description>Capillary gas chromatographic (GC) methods using sulphur and mass selective detection for the qualitative and quantitative determination of tetrahydrophtalimide (THPI) and 2-thiothiazolidine-4-carboxylic acid (TTCA), urinary metabolites of the fungicide captan in rat and humans, were developed. Urinary detection limits were 2.7 micrograms/l for THPI and 110 micrograms/l for TTCA. Intraperitoneal and oral administration of captan to rats resulted in a 48-h cumulative urinary excretion of THPI of 1%-2% and 3%-9% of the dose, respectively. Cumulative urinary excretion of TTCA over 48 h ranged from 2% to 5% of the captan dose for the respective routes of administration. In urine of non-exposed human subjects, neither THPI nor TTCA could be detected. In urine of fruit-growers who were occupationally exposed to captan, both THPI and TTCA could be detected. Based on these results, THPI and TTCA are proposed as promising parameters for the biological monitoring of occupational exposure to captan.</description><subject>Agriculture</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Captan - toxicity</subject><subject>Captan - urine</subject><subject>Chromatography, Gas</subject><subject>Environmental Monitoring - methods</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Occupational Exposure</subject><subject>Pesticides, fertilizers and other agrochemicals toxicology</subject><subject>Phthalimides - urine</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Sulfur</subject><subject>Thiazoles - urine</subject><subject>Thiazolidines</subject><subject>Toxicology</subject><issn>0340-0131</issn><issn>1432-1246</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1P3DAQhq2qiC7QS-9IPlQcEKF27MTJkc8WCamXco4m9qQxSuyt7Uhd_gR_uV52VQ4zc3gfPdK8hHzh7JIzpr5d3zMmGl7V9Qey4lKUBS9l_ZGsmJCsYFzwT-QoxmfGuKqVOCSHvOWK1c2KvN5iwjBbB8l6R_1AE6YA48YEvx4TTHa2Bik4Q8sijdbngRc_WWMdFrLQEHr_dzNZTUFbc0GXkF1hQ2dM0GcuYXyzjkiHxf22eqvTsE7gLqh1NECKb_pxmcHFE3IwwBTx8_4ek6f7u183P4rHn98fbq4eCy1kmYpeatkrZQyaqpHC9O12D63pVV-JimtmSqm4rEuGrdBDjptM6qaRTJXIxDE523nXwf9ZMKZutlHjNIFDv8SO1yJ3VJcZPN-BOvgYAw7dOtg5f9hx1m3b797bz_Dp3rr0M5p3dFd3zr_uc4gapiGA0zb-x2QrVVMJ8Q9Ht43W</recordid><startdate>19910101</startdate><enddate>19910101</enddate><creator>VAN WELIE, R. T. H</creator><creator>VAN DUYN, P</creator><creator>LAMME, E. K</creator><creator>JÄGER, P</creator><creator>VAN BAAR, B. L. M</creator><creator>VERMEULEN, N. P. E</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TV</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19910101</creationdate><title>Determination of tetrahydrophtalimide and 2-thiothiazolidine-4-carboxylic acid, urinary metabolites of the fungicide captan, in rats and humans</title><author>VAN WELIE, R. T. H ; VAN DUYN, P ; LAMME, E. K ; JÄGER, P ; VAN BAAR, B. L. M ; VERMEULEN, N. P. E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-b4c4b77dded5843db9843df9db7b5351c0d24714620e93cf9848d58c884072e03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Agriculture</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Captan - toxicity</topic><topic>Captan - urine</topic><topic>Chromatography, Gas</topic><topic>Environmental Monitoring - methods</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Occupational Exposure</topic><topic>Pesticides, fertilizers and other agrochemicals toxicology</topic><topic>Phthalimides - urine</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Sulfur</topic><topic>Thiazoles - urine</topic><topic>Thiazolidines</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>VAN WELIE, R. T. H</creatorcontrib><creatorcontrib>VAN DUYN, P</creatorcontrib><creatorcontrib>LAMME, E. K</creatorcontrib><creatorcontrib>JÄGER, P</creatorcontrib><creatorcontrib>VAN BAAR, B. L. M</creatorcontrib><creatorcontrib>VERMEULEN, N. P. E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>International archives of occupational and environmental health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>VAN WELIE, R. T. H</au><au>VAN DUYN, P</au><au>LAMME, E. K</au><au>JÄGER, P</au><au>VAN BAAR, B. L. M</au><au>VERMEULEN, N. P. E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determination of tetrahydrophtalimide and 2-thiothiazolidine-4-carboxylic acid, urinary metabolites of the fungicide captan, in rats and humans</atitle><jtitle>International archives of occupational and environmental health</jtitle><addtitle>Int Arch Occup Environ Health</addtitle><date>1991-01-01</date><risdate>1991</risdate><volume>63</volume><issue>3</issue><spage>181</spage><epage>186</epage><pages>181-186</pages><issn>0340-0131</issn><eissn>1432-1246</eissn><coden>IAEHDW</coden><abstract>Capillary gas chromatographic (GC) methods using sulphur and mass selective detection for the qualitative and quantitative determination of tetrahydrophtalimide (THPI) and 2-thiothiazolidine-4-carboxylic acid (TTCA), urinary metabolites of the fungicide captan in rat and humans, were developed. Urinary detection limits were 2.7 micrograms/l for THPI and 110 micrograms/l for TTCA. Intraperitoneal and oral administration of captan to rats resulted in a 48-h cumulative urinary excretion of THPI of 1%-2% and 3%-9% of the dose, respectively. Cumulative urinary excretion of TTCA over 48 h ranged from 2% to 5% of the captan dose for the respective routes of administration. In urine of non-exposed human subjects, neither THPI nor TTCA could be detected. In urine of fruit-growers who were occupationally exposed to captan, both THPI and TTCA could be detected. Based on these results, THPI and TTCA are proposed as promising parameters for the biological monitoring of occupational exposure to captan.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>1917068</pmid><doi>10.1007/BF00381566</doi><tpages>6</tpages></addata></record> |
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| ispartof | International archives of occupational and environmental health, 1991-01, Vol.63 (3), p.181-186 |
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| language | eng |
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| source | MEDLINE; Springer Online Journals Complete |
| subjects | Agriculture Animals Biological and medical sciences Captan - toxicity Captan - urine Chromatography, Gas Environmental Monitoring - methods Humans Male Medical sciences Occupational Exposure Pesticides, fertilizers and other agrochemicals toxicology Phthalimides - urine Rats Rats, Inbred Strains Sulfur Thiazoles - urine Thiazolidines Toxicology |
| title | Determination of tetrahydrophtalimide and 2-thiothiazolidine-4-carboxylic acid, urinary metabolites of the fungicide captan, in rats and humans |
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