Role for protein synthesis in the neurotoxic effects of methamphetamine in mice and rats

The mechanism by which the amphetamines damage selectively nigrostriatal dopaminergic neurons in experimental animals remains uncertain. The observation that neuronal cell death during embryogenesis involves an activation of gene expression and new protein synthesis, coupled with recent reports indi...

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Veröffentlicht in:	Brain research 1992-09, Vol.591 (1), p.160-164
Hauptverfasser:	Finnegan, Kevin T., Karler, Ralph
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anisomycin - pharmacology Biological and medical sciences Brain - drug effects Cycloheximide - pharmacology Dopamine - metabolism Male Medical sciences Methamphetamine Methamphetamine - toxicity Mice Nerve Tissue Proteins - biosynthesis Nervous system involvement in other diseases. Miscellaneous Neurology Neurotoxicity Parkinson's disease Programmed cell death Protein synthesis inhibition Rats Rats, Sprague-Dawley Rodentia Stereotypy
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