Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb

Anteroposterior polarity in the vertebrate limb is thought to be regulated in response to signals derived from a specialized region of distal posterior mesenchyme, the zone of polarizing activity. Sonic Hedgehog (Shh) is expressed in the zone of polarizing activity and appears to mediate the action...

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Veröffentlicht in:	Development (Cambridge) 1997-11, Vol.124 (21), p.4393-4404
Hauptverfasser:	Yang, Y, Drossopoulou, G, Chuang, P T, Duprez, D, Marti, E, Bumcrot, D, Vargesson, N, Clarke, J, Niswander, L, McMahon, A, Tickle, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Body Patterning CD4 Antigens - genetics CD4 Antigens - metabolism Cell Membrane - metabolism Chick Embryo COS Cells - metabolism Dose-Response Relationship, Drug Gene Expression Regulation, Developmental - drug effects Hedgehog Proteins Proteins - pharmacology Proteins - physiology Recombinant Proteins - genetics Recombinant Proteins - metabolism Signal Transduction Trans-Activators Wings, Animal - drug effects Wings, Animal - embryology
Online-Zugang:	Volltext
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