Deletion of Amino Acids 261−269 in the Brown Fat Uncoupling Protein Converts the Carrier into a Pore

The uncoupling protein (UCP) from brown adipose tissue mitochondria is a carrier that catalyzes proton re-entry into the matrix and thus dissipates the proton electrochemical potential gradient as heat. UCP activity is regulated:  purine nucleotides inhibit while fatty acids activate transport. We h...

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Veröffentlicht in:	Biochemistry (Easton) 1997-09, Vol.36 (36), p.10930-10935
Hauptverfasser:	González-Barroso, M. Mar, Fleury, Christophe, Levi-Meyrueis, Corinne, Zaragoza, Pilar, Bouillaud, Frédéric, Rial, Eduardo
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Transport - genetics Carrier Proteins - genetics Carrier Proteins - metabolism Gene Deletion Ion Channels Membrane Proteins - genetics Membrane Proteins - metabolism Mitochondria - metabolism Mitochondrial Proteins Mutagenesis, Site-Directed Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae - ultrastructure Uncoupling Agents - metabolism Uncoupling Protein 1
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