The effect of interleukin 12 desensitization on the antitumor efficacy of recombinant interleukin 12

Use of the cytokine interleukin 12 (IL-12) has been shown to enhance the rejection of a variety of murine tumors, but preclinical and clinical studies have revealed that recombinant IL-12 (rlL-12) can produce severe toxicity. In an effort to improve the tolerance and therapeutic effectiveness of thi...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1997-06, Vol.57 (12), p.2460-2467
Hauptverfasser:	COUGHLIN, C. M, WYSOCKA, M, TRINCHIERI, G, LEE, W. M. F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - toxicity Biological and medical sciences Drug toxicity and drugs side effects treatment Female Interferon-gamma - blood Interleukin-12 - administration & dosage Interleukin-12 - blood Interleukin-12 - toxicity Mammary Neoplasms, Experimental - drug therapy Medical sciences Melanoma - drug therapy Mice Mice, Inbred C3H Mice, Inbred Strains Miscellaneous (drug allergy, mutagens, teratogens...) Neoplasm Transplantation Pharmacology. Drug treatments Recombinant Proteins - administration & dosage Recombinant Proteins - blood Recombinant Proteins - toxicity Tumor Cells, Cultured
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