Bufalin reduces the level of topoisomerase II in human leukemia cells and affects the cytotoxicity of anticancer drugs

When human leukemia HL-60 cells were treated with 10 −7 M bufalin, the amounts of both topoisomerase (topo) IIα and IIβ and the activity of topo II decreased markedly and were almost undetectable 18 h after the start of treatment. The level of topo II mRNA started to decrease immediately after the s...

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Veröffentlicht in:	Leukemia research 1997-09, Vol.21 (9), p.875-883
Hauptverfasser:	Hashimoto, Sachiko, Jing, Yongkui, Kawazoe, Nobuko, Masuda, Yutaka, Nakajo, Shigeo, Yoshida, Takemi, Kuroiwa, Yukio, Nakaya, Kazuyasu
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents - pharmacology apoptosis Apoptosis - drug effects Biological and medical sciences Bufalin Bufanolides - pharmacology Cisplatin - pharmacology DNA Fragmentation DNA Topoisomerases, Type II - biosynthesis DNA Topoisomerases, Type II - genetics DNA, Neoplasm - analysis Drug Synergism Enzyme Induction - drug effects Enzyme Inhibitors - pharmacology General aspects HL-60 Cells - drug effects HL-60 Cells - enzymology Humans Isoenzymes - antagonists & inhibitors Isoenzymes - biosynthesis Isoenzymes - genetics leukemia cell Medical sciences Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Pharmacology. Drug treatments RNA, Messenger - biosynthesis RNA, Neoplasm - biosynthesis Tetradecanoylphorbol Acetate - pharmacology topoisomerase II Topoisomerase II Inhibitors Tretinoin - pharmacology
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