Virally directed cytosine deaminase/5-fluorocytosine gene therapy enhances radiation response in human cancer xenografts

Gene therapy combined with radiation therapy to enhance selectively radiation cytotoxicity in malignant cells represents a new approach for cancer treatment. We investigated the efficacy of adenoviral (Ad5)-directed cytosine deaminase/5-fluorocytosine (CD/5-FC) enzyme/prodrug gene therapy to enhance...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1997-10, Vol.57 (19), p.4205-4209
Hauptverfasser:	HANNA, N. N, MAUCERI, H. J, WAYNE, J. D, HALLAHAN, D. E, KUFE, D. W, WEICHSELBAUM, R. R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviruses, Human - genetics Animals Antimetabolites, Antineoplastic - therapeutic use Antineoplastic agents Biological and medical sciences Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - radiotherapy Carcinoma, Squamous Cell - therapy Combined Modality Therapy Combined treatments (chemotherapy of immunotherapy associated with an other treatment) Cytosine Deaminase Female Flucytosine - therapeutic use Genetic Therapy Genetic Vectors Humans Laryngeal Neoplasms - drug therapy Laryngeal Neoplasms - radiotherapy Laryngeal Neoplasms - therapy Medical sciences Mice Mice, Nude Neoplasm Recurrence, Local Neoplasm Transplantation Neoplasms, Experimental - drug therapy Neoplasms, Experimental - pathology Neoplasms, Experimental - radiotherapy Neoplasms, Experimental - therapy Nucleoside Deaminases - genetics Nucleoside Deaminases - therapeutic use Pharmacology. Drug treatments Radiation therapy and radiosensitizing agent Radiation Tolerance Radiation-Sensitizing Agents - therapeutic use Recombinant Fusion Proteins - therapeutic use Transfection Transplantation, Heterologous Treatment with physical agents Treatment. General aspects Tumors
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