Effects of gender and species on spectra of mutation induced by 2-amino-1-methyl-6-phenylimidazo[4,5- b]pyridine in the lacI transgene

Feeding of 2-amino-1-methyl-6-phenylimidazo[4,5- b]pyridine (PhIP) to F344 rats induces colon tumors specifically in male rats. Mutant frequencies and mutational spectra of the lacI transgene were studied in male and female Big Blue® transgenic rats after feeding 400 ppm of PhIP in the diet for 60 d...

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Veröffentlicht in:	Mutation research 1997-12, Vol.395 (2), p.93-99
Hauptverfasser:	Okonogi, Hideo, Stuart, Gregory R, Okochi, Eriko, Ushijima, Toshikazu, Sugimura, Takashi, Glickman, Barry W, Nagao, Minako
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Amino-1-methyl-6-phenylimidazo[4,5- b]pyridine Animals Animals, Genetically Modified Bacterial Proteins - drug effects Bacterial Proteins - genetics Carcinogens - toxicity Escherichia coli Proteins Female frequency Gender effect Imidazoles - toxicity Intestinal Mucosa - drug effects Lac Repressors lacI gene Male Mice Mutagens - toxicity Mutation Rats Rats, Inbred F344 Repressor Proteins - drug effects Repressor Proteins - genetics Sex Factors Species Specificity spectrum
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