Delayed therapy with a polymyxin B-dextran conjugate (PMX-622) improves survival in rabbits with Gram-negative peritonitis

Polymyxin B (PMB) is an amphipathic nephrotoxic antibiotic, which has been shown to neutralize the effects of endotoxin both in vitro and in vivo. PMB-D70 (PMX-622), a covalent conjugate of PMB with dextran 70 (D70), is less nephrotoxic than the parent compound. We sought to determine whether therap...

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Veröffentlicht in:	Journal of endotoxin research 1997-08, Vol.4 (4), p.285-292
Hauptverfasser:	Camerota, A.J., Lögdberg, L., Lake, P., Larkin, V.A., Fink, M.P.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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