Conus Peptides: Phylogenetic Range of Biological Activity
The major function of the venoms of the predatory marine snails belonging to the genus Conus is to paralyze prey. Thus, the venom of each Conus species acts on receptors and ion channels of the prey; previous studies suggested much less activity on homologous receptor targets in more distant taxa. I...
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| Veröffentlicht in: | The Biological bulletin 1992-08, Vol.183 (1), p.159-164 |
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| container_title | The Biological bulletin |
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| creator | Cruz, Lourdes J. Ramilo, Cecilia A. Corpuz, Gloria P. Olivera, Baldomero M. |
| description | The major function of the venoms of the predatory marine snails belonging to the genus Conus is to paralyze prey. Thus, the venom of each Conus species acts on receptors and ion channels of the prey; previous studies suggested much less activity on homologous receptor targets in more distant taxa. In this article, we address the question of whether some peptide components of Conus venoms ("conopeptides") have "cross-phylum" biological activity. We examined the venom of Conus textile, a mollusk-hunting Conus, using a mammalian biological activity assay. We purified a 23 amino acid "convulsant peptide" with potent activity in the mammalian CNS, even though it comes from the venom of a snail-hunting Conus species. A survey of Conus textile venom fractions indicates that, in addition to the convulsant peptide, many other components of this venom will exhibit "cross-phylum" biological activity. Conopeptides with broad-range phylogenetic specificity should be useful tools for studying the evolution of receptors and ion channels, and of nervous systems. |
| doi_str_mv | 10.2307/1542418 |
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Thus, the venom of each Conus species acts on receptors and ion channels of the prey; previous studies suggested much less activity on homologous receptor targets in more distant taxa. In this article, we address the question of whether some peptide components of Conus venoms ("conopeptides") have "cross-phylum" biological activity. We examined the venom of Conus textile, a mollusk-hunting Conus, using a mammalian biological activity assay. We purified a 23 amino acid "convulsant peptide" with potent activity in the mammalian CNS, even though it comes from the venom of a snail-hunting Conus species. A survey of Conus textile venom fractions indicates that, in addition to the convulsant peptide, many other components of this venom will exhibit "cross-phylum" biological activity. Conopeptides with broad-range phylogenetic specificity should be useful tools for studying the evolution of receptors and ion channels, and of nervous systems.</description><identifier>ISSN: 0006-3185</identifier><identifier>EISSN: 1939-8697</identifier><identifier>DOI: 10.2307/1542418</identifier><identifier>PMID: 29304567</identifier><language>eng</language><publisher>Woods Hole, MA: Marine Biological Laboratory</publisher><subject>Amino acids ; Analysis ; Animals ; Biochemistry ; Biological and medical sciences ; biological poisons ; Biological taxonomies ; Cell receptors ; Cell structures and functions ; Cellular biology ; channels ; Conus ; Convulsants ; Fundamental and applied biological sciences. Psychology ; ions ; Marine ; marine molluscs ; Miscellaneous ; Molecular and cellular biology ; Mollusca ; Mollusk venoms ; neurotoxicity ; Peptides ; Phylogenetics ; Physiological aspects ; Poisons ; Receptors ; Signaling Systems, Venoms, and Adhesives: Recurring Themes and Variations ; Snails ; Textiles ; toxicity ; Venom ; Venoms</subject><ispartof>The Biological bulletin, 1992-08, Vol.183 (1), p.159-164</ispartof><rights>Copyright 1992 The Marine Biological Laboratory</rights><rights>Copyright © 1992 by Marine Biological Laboratory</rights><rights>1993 INIST-CNRS</rights><rights>COPYRIGHT 1992 University of Chicago Press</rights><rights>Copyright Marine Biological Laboratory Aug 1992</rights><rights>In copyright. Digitized with the permission of the rights holder. http://creativecommons.org/licenses/by-nc-sa/3.0</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c493t-5f343f30d35caaa56b67f92ce1918cea2e3830085e7dd4e6f87d3fb52f6814d23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1542418$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1542418$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,885,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4417770$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29304567$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cruz, Lourdes J.</creatorcontrib><creatorcontrib>Ramilo, Cecilia A.</creatorcontrib><creatorcontrib>Corpuz, Gloria P.</creatorcontrib><creatorcontrib>Olivera, Baldomero M.</creatorcontrib><title>Conus Peptides: Phylogenetic Range of Biological Activity</title><title>The Biological bulletin</title><addtitle>Biol Bull</addtitle><description>The major function of the venoms of the predatory marine snails belonging to the genus Conus is to paralyze prey. Thus, the venom of each Conus species acts on receptors and ion channels of the prey; previous studies suggested much less activity on homologous receptor targets in more distant taxa. In this article, we address the question of whether some peptide components of Conus venoms ("conopeptides") have "cross-phylum" biological activity. We examined the venom of Conus textile, a mollusk-hunting Conus, using a mammalian biological activity assay. We purified a 23 amino acid "convulsant peptide" with potent activity in the mammalian CNS, even though it comes from the venom of a snail-hunting Conus species. A survey of Conus textile venom fractions indicates that, in addition to the convulsant peptide, many other components of this venom will exhibit "cross-phylum" biological activity. Conopeptides with broad-range phylogenetic specificity should be useful tools for studying the evolution of receptors and ion channels, and of nervous systems.</description><subject>Amino acids</subject><subject>Analysis</subject><subject>Animals</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>biological poisons</subject><subject>Biological taxonomies</subject><subject>Cell receptors</subject><subject>Cell structures and functions</subject><subject>Cellular biology</subject><subject>channels</subject><subject>Conus</subject><subject>Convulsants</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>ions</subject><subject>Marine</subject><subject>marine molluscs</subject><subject>Miscellaneous</subject><subject>Molecular and cellular biology</subject><subject>Mollusca</subject><subject>Mollusk venoms</subject><subject>neurotoxicity</subject><subject>Peptides</subject><subject>Phylogenetics</subject><subject>Physiological aspects</subject><subject>Poisons</subject><subject>Receptors</subject><subject>Signaling Systems, Venoms, and Adhesives: Recurring Themes and Variations</subject><subject>Snails</subject><subject>Textiles</subject><subject>toxicity</subject><subject>Venom</subject><subject>Venoms</subject><issn>0006-3185</issn><issn>1939-8697</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>79B</sourceid><recordid>eNp90V2L1DAUBuAiijuu4j-QIn5dWM1X28S72cGPhYVdRK9Dmp50MnSabpIOO__eLK27KOhVaXh4T3LeLHuO0QdCUf0Rl4wwzB9kKyyoKHgl6ofZCiFUFRTz8iR7EsIu_SKC2ePshAiKWFnVq0xs3DCF_ArGaFsIn_Kr7bF3HQwQrc6_q6GD3Jn8zLp0arXq87WO9mDj8Wn2yKg-wLPle5r9_PL5x-ZbcXH59Xyzvig0EzQWpaGMGopaWmqlVFk1VW0E0YAF5hoUAcopQryEum0ZVIbXLTVNSUzFMWsJPc3O59ywt3Eb3GDVIBvrWnsAH9JF5IFIp-wfZ71tvPJH6XwnR-WjJETgKmW9m7NG764nCFHubdDQ92oANwWJBRclpRyXib75P60oSpwl-PIvuHOTH9JK0lCU4nhNE3o_o071IO2g3RDhJmrX99CBTAvbXMo1TouoMBeJv5259i4ED0aO3u5vH4SRvC1cLoUn-WKZPjV7aO_c74YTeLUAFVJ9xqtB23DnGMN1XaPEXs9s0ttUc-dGDyHcP-V-3hK3C9H5f17rF000yVY</recordid><startdate>19920801</startdate><enddate>19920801</enddate><creator>Cruz, Lourdes J.</creator><creator>Ramilo, Cecilia A.</creator><creator>Corpuz, Gloria P.</creator><creator>Olivera, Baldomero M.</creator><general>Marine Biological Laboratory</general><general>University of Chicago Press</general><scope>IQODW</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TN</scope><scope>8FD</scope><scope>F1W</scope><scope>FR3</scope><scope>H95</scope><scope>K9.</scope><scope>L.G</scope><scope>P64</scope><scope>RC3</scope><scope>7QL</scope><scope>C1K</scope><scope>M81</scope><scope>7X8</scope><scope>79B</scope></search><sort><creationdate>19920801</creationdate><title>Conus Peptides: Phylogenetic Range of Biological Activity</title><author>Cruz, Lourdes J. ; Ramilo, Cecilia A. ; Corpuz, Gloria P. ; Olivera, Baldomero M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c493t-5f343f30d35caaa56b67f92ce1918cea2e3830085e7dd4e6f87d3fb52f6814d23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Amino acids</topic><topic>Analysis</topic><topic>Animals</topic><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>biological poisons</topic><topic>Biological taxonomies</topic><topic>Cell receptors</topic><topic>Cell structures and functions</topic><topic>Cellular biology</topic><topic>channels</topic><topic>Conus</topic><topic>Convulsants</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>ions</topic><topic>Marine</topic><topic>marine molluscs</topic><topic>Miscellaneous</topic><topic>Molecular and cellular biology</topic><topic>Mollusca</topic><topic>Mollusk venoms</topic><topic>neurotoxicity</topic><topic>Peptides</topic><topic>Phylogenetics</topic><topic>Physiological aspects</topic><topic>Poisons</topic><topic>Receptors</topic><topic>Signaling Systems, Venoms, and Adhesives: Recurring Themes and Variations</topic><topic>Snails</topic><topic>Textiles</topic><topic>toxicity</topic><topic>Venom</topic><topic>Venoms</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cruz, Lourdes J.</creatorcontrib><creatorcontrib>Ramilo, Cecilia A.</creatorcontrib><creatorcontrib>Corpuz, Gloria P.</creatorcontrib><creatorcontrib>Olivera, Baldomero M.</creatorcontrib><collection>Pascal-Francis</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Oceanic Abstracts</collection><collection>Technology Research Database</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Biochemistry Abstracts 3</collection><collection>MEDLINE - Academic</collection><collection>Biodiversity Heritage Library</collection><jtitle>The Biological bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cruz, Lourdes J.</au><au>Ramilo, Cecilia A.</au><au>Corpuz, Gloria P.</au><au>Olivera, Baldomero M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Conus Peptides: Phylogenetic Range of Biological Activity</atitle><jtitle>The Biological bulletin</jtitle><addtitle>Biol Bull</addtitle><date>1992-08-01</date><risdate>1992</risdate><volume>183</volume><issue>1</issue><spage>159</spage><epage>164</epage><pages>159-164</pages><issn>0006-3185</issn><eissn>1939-8697</eissn><abstract>The major function of the venoms of the predatory marine snails belonging to the genus Conus is to paralyze prey. Thus, the venom of each Conus species acts on receptors and ion channels of the prey; previous studies suggested much less activity on homologous receptor targets in more distant taxa. In this article, we address the question of whether some peptide components of Conus venoms ("conopeptides") have "cross-phylum" biological activity. We examined the venom of Conus textile, a mollusk-hunting Conus, using a mammalian biological activity assay. We purified a 23 amino acid "convulsant peptide" with potent activity in the mammalian CNS, even though it comes from the venom of a snail-hunting Conus species. A survey of Conus textile venom fractions indicates that, in addition to the convulsant peptide, many other components of this venom will exhibit "cross-phylum" biological activity. Conopeptides with broad-range phylogenetic specificity should be useful tools for studying the evolution of receptors and ion channels, and of nervous systems.</abstract><cop>Woods Hole, MA</cop><pub>Marine Biological Laboratory</pub><pmid>29304567</pmid><doi>10.2307/1542418</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Biological bulletin, 1992-08, Vol.183 (1), p.159-164 |
| issn | 0006-3185 1939-8697 |
| language | eng |
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| source | JSTOR Archive Collection A-Z Listing; EZB-FREE-00999 freely available EZB journals |
| subjects | Amino acids Analysis Animals Biochemistry Biological and medical sciences biological poisons Biological taxonomies Cell receptors Cell structures and functions Cellular biology channels Conus Convulsants Fundamental and applied biological sciences. Psychology ions Marine marine molluscs Miscellaneous Molecular and cellular biology Mollusca Mollusk venoms neurotoxicity Peptides Phylogenetics Physiological aspects Poisons Receptors Signaling Systems, Venoms, and Adhesives: Recurring Themes and Variations Snails Textiles toxicity Venom Venoms |
| title | Conus Peptides: Phylogenetic Range of Biological Activity |
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