Alternative method of oral administration by peanut butter pellet formulation results in target engagement of BACE1 and attenuation of gavage-induced stress responses in mice

Development of novel therapeutic agents aimed at treating neurodegenerative disorders such as Alzheimer's and Parkinson's diseases require chronic and preferentially oral dosing in appropriate preclinical rodent models. Since many of these disease models involve transgenic mice that are fr...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 2014-11, Vol.126, p.28-35
Hauptverfasser:	Gonzales, C., Zaleska, M.M., Riddell, D.R., Atchison, K.P., Robshaw, A., Zhou, H., Sukoff Rizzo, S.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Amyloid beta-Peptides - blood Amyloid Precursor Protein Secretases - antagonists & inhibitors Amyloid Precursor Protein Secretases - metabolism Animals Arachis Aspartic Acid Endopeptidases - antagonists & inhibitors Aspartic Acid Endopeptidases - metabolism BACE1 Brain - metabolism Chemistry, Pharmaceutical Chronic oral dosing method Corticosterone Corticosterone - blood Drug Delivery Systems - methods Enzyme Inhibitors - administration & dosage Enzyme Inhibitors - pharmacokinetics Enzyme Inhibitors - pharmacology Fever - blood Intubation, Gastrointestinal - adverse effects Male Mice Mice, Transgenic Mouse Peptide Fragments - blood Restraint, Physical Stress Stress, Physiological - drug effects
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